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Evolutionary relationship of HLA-DRB genes inferred from intron sequences
https://ir.soken.ac.jp/records/3671
https://ir.soken.ac.jp/records/36717c13c8d8-bc61-46ac-ac70-e917d58e5808
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-27 | |||||
| タイトル | ||||||
| タイトル | Evolutionary relationship of HLA-DRB genes inferred from intron sequences | |||||
| タイトル | ||||||
| タイトル | Evolutionary relationship of HLA-DRB genes inferred from intron sequences | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
SATTA, Yoko
× SATTA, Yoko× MAYER, Werner E× KLEIN, Jan |
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| 著者別名 |
颯田, 葉子
× 颯田, 葉子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The major histocompatibility complex (Mhc) consists of class I and class II genes. In the humanMhc (HLA) class II genes, nineDRB loci have been identified. To elucidate the origin of these duplicated loci and allelic divergences at the most polymorphicDRBI locus, introns 4 and 5 as well as the 3′ untranslated region (altogether approximately 1,000 base pairs) of sevenHLA-DRB loci, threeHLA-DRBI alleles, and nine nonhuman primateDRB genes were examined. It is shown that there were two major diversification events inHLA-DRB genes, each involving gene duplications and allelic divergences. Approximately 50 million years (my) ago,DRBI *04 and an ancestor of theDRB1 *03 cluster (DRBI *03, DRBI*15, andDRB3) diverged from each other andDRB5, DRB7, DRB8, and an ancestor of theDRB2 cluster (DRB2, DRB4, andDRB6) arose by gene duplication. Later, about 25 my ago,DRBI *15 diverged fromDRBI*03, andDRB3 was duplicated fromDRBI *03. Then, some 20 my ago, the lineage leading to theDRB2 cluster produced two new loci,DRB4 andDRB6. TheDRBI *03 andDRBI *04 allelic lineages are extraordinarily old and have persisted longer than some duplicated genes. The orthologous relationships ofDRB genes between human and Old World monkeys are apparent, but those between Catarrhini and New World monkeys are equivocal because of a rather rapid expansion and contraction of primateDRB genes by duplication and deletion. | |||||
| 書誌情報 |
Journal of Molecular Evolution en : Journal of Molecular Evolution 巻 42, 号 6, p. 648-657, 発行日 1996-06 |
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| 出版者 | ||||||
| 出版者 | SpringerLink | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00222844 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 8662017 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://doi.org/10.1007/BF02338798 | |||||
| 関連名称 | 10.1007/BF02338798 | |||||
| 権利 | ||||||
| 権利情報 | SpringerLink(The original publication is available at www.springerlink.com) | |||||
