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The molecular descent of the major histocompatibility complex
https://ir.soken.ac.jp/records/3682
https://ir.soken.ac.jp/records/3682397c0f1c-51f4-4127-977e-e9e67b4cd531
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-07-02 | |||||
| タイトル | ||||||
| タイトル | The molecular descent of the major histocompatibility complex | |||||
| タイトル | ||||||
| タイトル | The molecular descent of the major histocompatibility complex | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
KLEIN, Jan
× KLEIN, Jan× SATTA, Yoko× O'HUIGIN, Colm× TAKAHATA, Naoyuki |
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| 著者別名 |
尚之, 高畑
× 尚之, 高畑 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the last few years, more than 500 primate major histocompatibility complex (Mhc) genes or parts thereof have been sequenced. The extraordinary sequence information is used here to draw conclusions about the manner of Mhc evolution. The Mhc genes are found to evolve at a relatively slow rate with the regularity of a clock. It takes from 1 to 6 million years for a new mutation to be incorporated into an Mhc allele, and the mutation rate is comparable to that of most other primate genes. The nonsynonymous sites coding for the peptide-binding region (PBR) are under relatively weak positive selection pressure (selection coefficient of a few percent only); the nonsynonymous non-PBR sites are under moderate negative selection pressure. The positive pressure is probably provided by parasites and is responsible for the trans-species persistence of allelic lineages at functional Mhc loci for more than 40 million years. | |||||
| 書誌情報 |
Annual Review of Immunology en : Annual Review of Immunology 巻 11, p. 269-295, 発行日 1993 |
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| 出版者 | ||||||
| 出版者 | Annual Reviews | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 07320582 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 8476562 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1146/annurev.iy.11.040193.001413 | |||||
| 関連名称 | 10.1146/annurev.iy.11.040193.001413 | |||||
| 権利 | ||||||
| 権利情報 | © 1993 by Annual Reviews Inc. | |||||
