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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

The molecular descent of the major histocompatibility complex

https://ir.soken.ac.jp/records/3682
https://ir.soken.ac.jp/records/3682
397c0f1c-51f4-4127-977e-e9e67b4cd531
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-02
タイトル
タイトル The molecular descent of the major histocompatibility complex
タイトル
言語 en
タイトル The molecular descent of the major histocompatibility complex
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 KLEIN, Jan

× KLEIN, Jan

WEKO 1552

KLEIN, Jan

Search repository
SATTA, Yoko

× SATTA, Yoko

WEKO 357

SATTA, Yoko

Search repository
O'HUIGIN, Colm

× O'HUIGIN, Colm

WEKO 1578

O'HUIGIN, Colm

Search repository
TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

WEKO 778

TAKAHATA, Naoyuki

Search repository
著者別名 尚之, 高畑

× 尚之, 高畑

WEKO 1577
NRID 1000030124217
e-Rad 30124217

尚之, 高畑

Search repository
抄録
内容記述タイプ Abstract
内容記述 In the last few years, more than 500 primate major histocompatibility complex (Mhc) genes or parts thereof have been sequenced. The extraordinary sequence information is used here to draw conclusions about the manner of Mhc evolution. The Mhc genes are found to evolve at a relatively slow rate with the regularity of a clock. It takes from 1 to 6 million years for a new mutation to be incorporated into an Mhc allele, and the mutation rate is comparable to that of most other primate genes. The nonsynonymous sites coding for the peptide-binding region (PBR) are under relatively weak positive selection pressure (selection coefficient of a few percent only); the nonsynonymous non-PBR sites are under moderate negative selection pressure. The positive pressure is probably provided by parasites and is responsible for the trans-species persistence of allelic lineages at functional Mhc loci for more than 40 million years.
書誌情報 Annual Review of Immunology
en : Annual Review of Immunology

巻 11, p. 269-295, 発行日 1993
出版者
出版者 Annual Reviews
ISSN
収録物識別子タイプ ISSN
収録物識別子 07320582
PubMed番号
識別子タイプ PMID
関連識別子 8476562
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1146/annurev.iy.11.040193.001413
関連名称 10.1146/annurev.iy.11.040193.001413
権利
権利情報 © 1993 by Annual Reviews Inc.
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