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Selection, convergence, and intragenic recombination in HLA diversity
https://ir.soken.ac.jp/records/3688
https://ir.soken.ac.jp/records/3688ddfca270-b218-4a51-a2e0-f18241c07211
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-07-02 | |||||
| タイトル | ||||||
| タイトル | Selection, convergence, and intragenic recombination in HLA diversity | |||||
| タイトル | ||||||
| タイトル | Selection, convergence, and intragenic recombination in HLA diversity | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
TAKAHATA, Naoyuki
× TAKAHATA, Naoyuki× SATTA, Yoko |
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| 著者別名 |
尚之 , 高畑
× 尚之 , 高畑 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To account for high degrees of human leukocyte antigen (HLA) diversity, a method is proposed for detecting intragenic recombination or gene conversion separately from parallel substitutions or convergent evolution. An application of the method to HLA protein sequences suggests that intragenic recombination played important roles in HLA-B and DPB1, some in HLA-A and DRB1, and least in HLA-C and DQB1 diversity. However, the extent of diversity of these molecules does not necessarily correlate with the frequency of intragenic recombination, supporting the view that (balancing) selection is a primary agent of HLA diversity and often leads to convergent evolution. Computer simulation is carried out to examine two models of balancing selection under the coupled effect with mutation, intragenic recombination, and random drift in a diploid population. It is emphasized that break points by intragenic recombination need be specified to account for HLA diversity. Implications of HLA diversity in human evolution are briefly discussed. | |||||
| 書誌情報 |
Genetica en : Genetica 巻 102-103, p. 157-169, 発行日 1998 |
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| 出版者 | ||||||
| 出版者 | SpringerLink | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00166707 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 9720277 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1023/A:1017029613342 | |||||
| 関連名称 | 10.1023/A:1017029613342 | |||||
| 権利 | ||||||
| 権利情報 | SpringerLink(The original publication is available at www.springerlink.com) | |||||
