| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-07-03 |
| タイトル |
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|
タイトル |
Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates |
| タイトル |
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タイトル |
Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
GO, Yasuhiro
SATTA, Yoko
TAKENAKA, Osamu
TAKAHATA, Naoyuki
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Since the process of becoming dead genes or pseudogenes (pseudogenization) is irreversible and can occur rather rapidly under certain environmental circumstances, it is one plausible determinant for characterizing species specificity. To test this evolutionary hypothesis, we analyzed the tempo and mode of duplication and pseudogenization of bitter taste receptor (T2R) genes in humans as well as in 12 nonhuman primates. The results show that primates have accumulated more pseudogenes than mice after their separation from the common ancestor and that lineage-specific pseudogenization becomes more conspicuous in humans than in nonhuman primates. Although positive selection has operated on some amino acids in extracellular domains, functional constraints against T2R genes are more relaxed in primates than in mice and this trend has culminated in the rapid deterioration of the bitter-tasting capability in humans. Since T2R molecules play an important role in avoiding generally bitter toxic and harmful substances, substantial modification of the T2R gene repertoire is likely to reflect different responses to changes in the environment and to result from species-specific food preference during primate evolution. |
| 書誌情報 |
Genetics
en : Genetics
巻 170,
号 1,
p. 313-326,
発行日 2005-05
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| 出版者 |
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出版者 |
The Genetics Society of America |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00166731 |
| PubMed番号 |
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|
識別子タイプ |
PMID |
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関連識別子 |
15744053 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1534/genetics.104.037523 |
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|
関連名称 |
10.1534/genetics.104.037523 |
| 権利 |
|
|
権利情報 |
© 2013 by The Genetics Society of America |
