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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Polymorphism and balancing selection at major histocompatibility complex loci

https://ir.soken.ac.jp/records/3704
https://ir.soken.ac.jp/records/3704
6fd825fb-0a5b-45b6-a186-8fa8d2080732
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-03
タイトル
タイトル Polymorphism and balancing selection at major histocompatibility complex loci
タイトル
言語 en
タイトル Polymorphism and balancing selection at major histocompatibility complex loci
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

WEKO 778

TAKAHATA, Naoyuki

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SATTA, Yoko

× SATTA, Yoko

WEKO 357

SATTA, Yoko

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KLEIN, Jan

× KLEIN, Jan

WEKO 1552

KLEIN, Jan

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著者別名 尚之, 高畑

× 尚之, 高畑

WEKO 1577
NRID 1000030124217
e-Rad 30124217

尚之, 高畑

Search repository
抄録
内容記述タイプ Abstract
内容記述 Amino acid replacements in the peptide-binding region (PBR) of the functional major histocompatibility complex (Mhc) genes appear to be driven by balancing selection. Of the various types of balancing selection, we have examined a model equivalent to overdominance that confers heterozygote advantage. As discussed by A. Robertson, overdominance selection tends to maintain alleles that have more or less the same degree of heterozygote advantage. Because of this symmetry, the model makes various testable predictions about the genealogical relationships among different alleles and provides ways of analyzing DNA sequences of Mhc alleles. In this paper, we analyze DNA sequences of 85 alleles at the HLA-A, -B, -C, -DRB1 and -DQB1 loci with respect to the number of alleles and extent of nucleotide differences at the PBR, as well as at the synonymous (presumably neutral) sites. Theory suggests that the number of alleles that differ at the sites targeted by selection (presumably the nonsynonymous sites in the PBR) should be equal to the mean number of nucleotide substitutions among pairs of alleles. We also demonstrate that the nucleotide substitution rate at the targeted sites relative to that of neutral sites may be much larger than 1. The predictions of the presented model are in surprisingly good agreement with the actual data and thus provide means for inferring certain population parameters. For overdominance selection in a finite population at equilibrium, the product of selection intensity (s) against homozygotes and the effective population size (N) is estimated to be 350-3000, being largest at the B locus and smallest at the C locus. We argue that N is of the order of 10(5) and s is several percent at most, if the mutation rate per site per generation is 10(-8).
書誌情報 Genetics
en : Genetics

巻 130, 号 4, p. 925-938, 発行日 1992
出版者
出版者 The Genetics Society of America
ISSN
収録物識別子タイプ ISSN
収録物識別子 00166731
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 1582567
権利
権利情報 © 1992 by The Genetics Society of America
関連サイト
識別子タイプ URI
関連識別子 http://www.genetics.org/content/130/4/925.short
関連名称 The Genetics Society of America
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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