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Polymorphism and balancing selection at major histocompatibility complex loci
https://ir.soken.ac.jp/records/3704
https://ir.soken.ac.jp/records/37046fd825fb-0a5b-45b6-a186-8fa8d2080732
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2013-07-03 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Polymorphism and balancing selection at major histocompatibility complex loci | |||||||||||
| タイトル | ||||||||||||
| タイトル | Polymorphism and balancing selection at major histocompatibility complex loci | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | metadata only access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||||
| 著者 |
TAKAHATA, Naoyuki
× TAKAHATA, Naoyuki
× SATTA, Yoko
× KLEIN, Jan
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| 著者別名 |
尚之, 高畑
× 尚之, 高畑
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Amino acid replacements in the peptide-binding region (PBR) of the functional major histocompatibility complex (Mhc) genes appear to be driven by balancing selection. Of the various types of balancing selection, we have examined a model equivalent to overdominance that confers heterozygote advantage. As discussed by A. Robertson, overdominance selection tends to maintain alleles that have more or less the same degree of heterozygote advantage. Because of this symmetry, the model makes various testable predictions about the genealogical relationships among different alleles and provides ways of analyzing DNA sequences of Mhc alleles. In this paper, we analyze DNA sequences of 85 alleles at the HLA-A, -B, -C, -DRB1 and -DQB1 loci with respect to the number of alleles and extent of nucleotide differences at the PBR, as well as at the synonymous (presumably neutral) sites. Theory suggests that the number of alleles that differ at the sites targeted by selection (presumably the nonsynonymous sites in the PBR) should be equal to the mean number of nucleotide substitutions among pairs of alleles. We also demonstrate that the nucleotide substitution rate at the targeted sites relative to that of neutral sites may be much larger than 1. The predictions of the presented model are in surprisingly good agreement with the actual data and thus provide means for inferring certain population parameters. For overdominance selection in a finite population at equilibrium, the product of selection intensity (s) against homozygotes and the effective population size (N) is estimated to be 350-3000, being largest at the B locus and smallest at the C locus. We argue that N is of the order of 10(5) and s is several percent at most, if the mutation rate per site per generation is 10(-8). | |||||||||||
| 書誌情報 |
Genetics en : Genetics 巻 130, 号 4, p. 925-938, 発行日 1992 |
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| 出版者 | ||||||||||||
| 出版者 | The Genetics Society of America | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 00166731 | |||||||||||
| PubMed番号 | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 1582567 | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | © 1992 by The Genetics Society of America | |||||||||||
| 関連サイト | ||||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | http://www.genetics.org/content/130/4/925.short | |||||||||||
| 関連名称 | The Genetics Society of America | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
