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  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Gene genealogy and variance of interpopulational nucleotide differences

https://ir.soken.ac.jp/records/3711
https://ir.soken.ac.jp/records/3711
a4346150-e439-473c-96bc-4a7d0a44e54d
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-03
タイトル
タイトル Gene genealogy and variance of interpopulational nucleotide differences
タイトル
タイトル Gene genealogy and variance of interpopulational nucleotide differences
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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NEI, Masatoshi

× NEI, Masatoshi

NEI, Masatoshi

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 A mathematical theory is developed for computing the probability that m genes sampled from one population (species) and n genes sampled from another are derived from l genes that existed at the time of population splitting. The expected time of divergence between the two most closely related genes sampled from two different populations and the time of divergence (coalescence) of all genes sampled are studied by using this theory. It is shown that the time of divergence between the two most closely related genes can be used as an approximate estimate of the time of population splitting (T) only when T ≡ t/(2 N) is small, where t and N are the number of generations and the effective population size, respectively. The variance of Nei and Li's estimate (d) of the number of net nucleotide differences between two populations is also studied. It is shown that the standard error (sd) of d is larger than the mean when T is small (T << 1). In this case, sd is reduced considerably by increasing sample size. When T is large (T > 1), however, a large proportion of the variance of d is caused by stochastic factors, and increase in the sample size does not help to reduce sd. To reduce the stochastic variance of d, one must use data from many independent unlinked gene loci.
書誌情報 Genetics
en : Genetics

巻 110, 号 2, p. 325-344, 発行日 1985
出版者
出版者 The Genetics Society of America
ISSN
収録物識別子タイプ ISSN
収録物識別子 00166731
PubMed番号
識別子タイプ PMID
関連識別子 4007484
権利
権利情報 © 1985 by The Genetics Society of America
関連サイト
識別子タイプ URI
関連識別子 http://www.genetics.org/content/110/2/325.short
関連名称 The Genetics Society of America
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