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A model of evolutionary base substitutions and its application with special reference to rapid change of pseudogenes
https://ir.soken.ac.jp/records/3714
https://ir.soken.ac.jp/records/37149ef27dc7-7c7c-495c-94f4-c8a4ad56efd3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2013-07-03 | |||||||||
| タイトル | ||||||||||
| タイトル | A model of evolutionary base substitutions and its application with special reference to rapid change of pseudogenes | |||||||||
| タイトル | ||||||||||
| タイトル | A model of evolutionary base substitutions and its application with special reference to rapid change of pseudogenes | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | metadata only access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||
| 著者 |
TAKAHATA, Naoyuki
× TAKAHATA, Naoyuki
× KIMURA, Motoo
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| 著者別名 |
尚之, 高畑
× 尚之, 高畑
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | A model of evolutionary base substitutions that can incorporate different substitutional rates between the four bases and that takes into account unequal composition of bases in DNA sequences is proposed. Using this model, we derived formulae that enable us to estimate the evolutionary distances in terms of the number of nucleotide substitutions through comparative studies of nucleotide sequences. In order to check the validity of various formulae, Monte Carlo experiments were performed. These formulae were applied to analyze data on DNA sequences from diverse organisms. Particular attention was paid to problems concerning a globin pseudogene in the mouse and the time of its origin through duplication. We obtained a result suggesting that the evolutionary rates of substitution in the first and second codon positions of the pseudogene were roughly 10 times faster than those in the normal globin genes; whereas, the rate in the third position remained almost unchanged. Application of our formulae to histone genes H2B and H3 of the sea urchin showed that, in each of these genes, the rate in the third codon position is tremendously higher than that in the second position. All of these observations can easily and consistently be interpreted by the neutral theory of molecular evolution. | |||||||||
| 書誌情報 |
Genetics en : Genetics 巻 98, 号 3, p. 641-657, 発行日 1981 |
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| 出版者 | ||||||||||
| 出版者 | The Genetics Society of America | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 00166731 | |||||||||
| PubMed番号 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 7333455 | |||||||||
| 権利 | ||||||||||
| 権利情報 | © 1981 by The Genetics Society of America | |||||||||
| 関連サイト | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://www.genetics.org/content/98/3/641.short | |||||||||
| 関連名称 | The Genetics Society of America | |||||||||
