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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

The origin and evolution of human ampliconic gene families and ampliconic structure

https://ir.soken.ac.jp/records/3717
https://ir.soken.ac.jp/records/3717
f491ca72-4e94-43e3-86cb-3c4ed5e7c360
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-03
タイトル
タイトル The origin and evolution of human ampliconic gene families and ampliconic structure
タイトル
タイトル The origin and evolution of human ampliconic gene families and ampliconic structure
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 BHOWMICK, Bejon Kumar

× BHOWMICK, Bejon Kumar

BHOWMICK, Bejon Kumar

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SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 Out of the nine male-specific gene families in the human Y chromosome amplicons, we investigate the origin and evolution of seven families for which gametologous and orthologous sequences are available. Proto-X/Y gene pairs in the original mammalian sex chromosomes played major roles in origins and gave rise to five gene families: XKRY, VCY, HSFY, RBMY, and TSPY. The divergence times between gametologous X- and Y-linked copies in these families are well correlated with the former X-chromosomal locations. The CDY and DAZ families originated exceptionally by retroposition and transposition of autosomal copies, respectively, but CDY possesses an X-linked copy of enigmatic origin. We also investigate the evolutionary relatedness among Y-linked copies of a gene family in light of their ampliconic locations (palindromes, inverted repeats, and the TSPY array). Although any pair of copies located at the same arm positions within a palindrome is identical or nearly so by frequent gene conversion, copies located at different arm positions are distinctively different. Since these and other distinct copies in various gene families were amplified almost simultaneously in the stem lineage of Catarrhini, we take these simultaneous amplifications as evidence for the elaborate formation of Y ampliconic structure. Curiously, some copies in a gene family located at different palindromes exhibit high sequence similarity, and in most cases, such similarity greatly extends to repeat units that harbor these copies. It appears that such palindromic repeat units have evolved by and large en bloc, but they have undergone frequent exchanges between palindromes.
書誌情報 Genome Research
en : Genome Research

巻 17, 号 4, p. 441-450, 発行日 2007-04
出版者
出版者 Cold Spring Harbor Laboratory Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 10889051
PubMed番号
識別子タイプ PMID
関連識別子 17185645
DOI
識別子タイプ DOI
関連識別子 http://doi.org/10.1101/gr.5734907
関連名称 10.1101/gr.5734907
権利
権利情報 © 2013 by Cold Spring Harbor Laboratory Press
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