| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-07-03 |
| タイトル |
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タイトル |
Polymorphism of the HLA class II loci in Siberian populations |
| タイトル |
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タイトル |
Polymorphism of the HLA class II loci in Siberian populations |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
GRAHOVAC, Blazenka
SUKERNIK, Rem I
O’HUIGIN, Colm
ZOFIA, Zaleska-Rutczyńska
NADEZHDA, Blagitko
OLGA, Raldugina
TANJA, Košutić
SATTA, Yoko
FELIPE, Figueroa
TAKAHATA, Naoyuki
KLEIN, Jan
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The populations that colonized Siberia diverged from one another in the Paleolithic and evolved in isolation until today. These populations are therefore a rich source of information about the conditions under which the initial divergence of modern humans occurred. In the present study we used the HLA system, first, to investigate the evolution of the human major histocompatibility complex (MHC) itself, and second, to reveal the relationships among Siberian populations. We determined allelic frequencies at five HLA class II loci (DRB1, DQA1, DQB1, DPA1, and DPB1) in seven Siberian populations (Ket, Evenk, Koryak, Chukchi, Nivkh, Udege, and Siberian Eskimo) by the combination of single-stranded conformational polymorphism and DNA sequencing analysis. We then used the gene frequency data to deduce the HLA class II haplotypes and their frequencies. Despite high polymorphism at four of the five loci, no new alleles could be detected. This finding is consistent with a conserved evolution of human class II MHC genes. We found a high number of HLA class II haplotypes in Siberian populations. More haplotypes have been found in Siberia than in any other population. Some of the haplotypes are shared with non-Siberian populations, but most of them are new, and some represent “forbidden” combinations of DQA1 and DQB1 alleles. We suggest that a set of “public” haplotypes was brought to Siberia with the colonizers but that most of the new haplotypes were generated in Siberia by recombination and are part of a haplotype pool that is turning over rapidly. The allelic frequencies at the DRB1 locus divide the Siberian populations into eastern and central Siberian branches; only the former shows a clear genealogical relationship to Amerinds. |
| 書誌情報 |
Human Genetics
en : Human Genetics
巻 102,
号 1,
p. 27-43,
発行日 1998
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| 出版者 |
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出版者 |
SpringerLink |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03406717 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
9490295 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
http://doi.org/10.1007/s004390050650 |
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|
関連名称 |
10.1007/s004390050650 |
| 権利 |
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|
権利情報 |
SpringerLink(The original publication is available at www.springerlink.com) |
