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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Mhc class II B gene evolution in East African cichlid fishes

https://ir.soken.ac.jp/records/3719
https://ir.soken.ac.jp/records/3719
58adcc08-2c35-431e-a12a-e389056b2877
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-03
タイトル
タイトル Mhc class II B gene evolution in East African cichlid fishes
タイトル
タイトル Mhc class II B gene evolution in East African cichlid fishes
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 FIGUEROA, Felipe

× FIGUEROA, Felipe

FIGUEROA, Felipe

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MAYER, Werner E.

× MAYER, Werner E.

MAYER, Werner E.

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SülTMANN, Holger A

× SülTMANN, Holger A

SülTMANN, Holger A

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O’HUGIN, Colm

× O’HUGIN, Colm

O’HUGIN, Colm

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TICHY, Herbert

× TICHY, Herbert

TICHY, Herbert

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SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

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TAKEZAKI, Naoko

× TAKEZAKI, Naoko

TAKEZAKI, Naoko

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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KLEIN, Jan

× KLEIN, Jan

KLEIN, Jan

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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内容記述タイプ Abstract
内容記述 A distinctive feature of essential major histocompatibility complex (Mhc) loci is their polymorphism characterized by large genetic distances between alleles and long persistence times of allelic lineages. Since the lineages often span several successive speciations, we investigated the behavior of the Mhc alleles during or close to the speciation phase. We sequenced exon 2 of the class II B locus 4 from 232 East African cichlid fishes representing 32 related species. The divergence times of the (sub)species ranged from 6000 to 8.4 million years. Two types of evolutionary analysis were used to elucidate the pattern of exon 2 sequence divergence. First, phylogenetic methods were applied to reconstruct the most likely evolutionary pathways leading from the last common ancestor of the set to the extant sequences, and to assess the probable mechanisms involved in allelic diversification. Second, pairwise comparisons of sequences were carried out to detect differences seemingly incompatible with origin by nonparallel point mutations. The analysis revealed point mutations to be the most important mechanism behind allelic divergences, with recombination playing only an auxiliary part. Comparison of sequences from related species revealed evidence of random allelic (lineage) losses apparently associated with speciation. Sharing of identical alleles could be demonstrated between species that diverged 2 million years ago. The phylogeny of the exon was incongruent with that of the flanking introns, indicating either a high degree of convergent evolution at the peptide-binding region-encoding sites, or intron homogenization.
書誌情報 Immunogenetics
en : Immunogenetics

巻 51, 号 7, p. 556-575, 発行日 2000
出版者
出版者 SpringerLink
ISSN
収録物識別子タイプ ISSN
収録物識別子 00937711
PubMed番号
識別子タイプ PMID
関連識別子 10912507
DOI
識別子タイプ DOI
関連識別子 http://doi.org/10.1007/s002510000181
関連名称 10.1007/s002510000181
権利
権利情報 SpringerLink(The original publication is available at www.springerlink.com)
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