| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-07-03 |
| タイトル |
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|
タイトル |
Mhc class II B gene evolution in East African cichlid fishes |
| タイトル |
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タイトル |
Mhc class II B gene evolution in East African cichlid fishes |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
FIGUEROA, Felipe
MAYER, Werner E.
SülTMANN, Holger A
O’HUGIN, Colm
TICHY, Herbert
SATTA, Yoko
TAKEZAKI, Naoko
TAKAHATA, Naoyuki
KLEIN, Jan
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
A distinctive feature of essential major histocompatibility complex (Mhc) loci is their polymorphism characterized by large genetic distances between alleles and long persistence times of allelic lineages. Since the lineages often span several successive speciations, we investigated the behavior of the Mhc alleles during or close to the speciation phase. We sequenced exon 2 of the class II B locus 4 from 232 East African cichlid fishes representing 32 related species. The divergence times of the (sub)species ranged from 6000 to 8.4 million years. Two types of evolutionary analysis were used to elucidate the pattern of exon 2 sequence divergence. First, phylogenetic methods were applied to reconstruct the most likely evolutionary pathways leading from the last common ancestor of the set to the extant sequences, and to assess the probable mechanisms involved in allelic diversification. Second, pairwise comparisons of sequences were carried out to detect differences seemingly incompatible with origin by nonparallel point mutations. The analysis revealed point mutations to be the most important mechanism behind allelic divergences, with recombination playing only an auxiliary part. Comparison of sequences from related species revealed evidence of random allelic (lineage) losses apparently associated with speciation. Sharing of identical alleles could be demonstrated between species that diverged 2 million years ago. The phylogeny of the exon was incongruent with that of the flanking introns, indicating either a high degree of convergent evolution at the peptide-binding region-encoding sites, or intron homogenization. |
| 書誌情報 |
Immunogenetics
en : Immunogenetics
巻 51,
号 7,
p. 556-575,
発行日 2000
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| 出版者 |
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出版者 |
SpringerLink |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00937711 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
10912507 |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
http://doi.org/10.1007/s002510000181 |
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関連名称 |
10.1007/s002510000181 |
| 権利 |
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|
権利情報 |
SpringerLink(The original publication is available at www.springerlink.com) |
