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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Footprints of intragenic recombination at HLA loci

https://ir.soken.ac.jp/records/3721
https://ir.soken.ac.jp/records/3721
a8c1fac2-12b1-4a92-abec-ce455eb8b189
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-04
タイトル
タイトル Footprints of intragenic recombination at HLA loci
タイトル
タイトル Footprints of intragenic recombination at HLA loci
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 To evaluate the effect of balancing selection and intragenic recombination (or gene conversion) at six individual HLA loci, synonymous nucleotide diversity in different exon groups is examined within (πw) and between (πb) allelic lineages that may be defined by either serological or DNA sequence differences. Both π values are high in exons which encode for the peptide binding region (PBR) and tend to decrease in other exons. The value of πw is significantly smaller than that of πb in any exon of any locus. However, even πw is much greater than nucleotide diversity at non-HLA loci. These observations provide additional strong evidence for the operation of balancing selection in PBR-encoding exons and its indirect effects on polymorphism at linked neighboring regions. It appears that allelic lineages have generally evolved in isolation but the linkage relationships within and between exons are incomplete throughout the long evolutionary history. To quantify intragenic recombination and account for the large discrepancy between the HLA and non-HLA diversity, a population genetics model is analyzed with special reference to the evolution of modern humans. The analysis suggests that the recombination rate between two sites 1000 base pairs apart is about 10–5 per generation and that the effective size of human populations (equivalent roughly to the number of breeding individuals in a randomly mating population) has dropped from 105 to 104 in most of the Quaternary. One possibility for this reduction is discussed.
書誌情報 Immunogenetics
en : Immunogenetics

巻 47, 号 6, p. 430-441, 発行日 1998
出版者
出版者 SpringerLink
ISSN
収録物識別子タイプ ISSN
収録物識別子 00937711
PubMed番号
識別子タイプ PMID
関連識別子 9553149
DOI
識別子タイプ DOI
関連識別子 http://doi.org/10.1007/s002510050380
関連名称 10.1007/s002510050380
権利
権利情報 SpringerLink(The original publication is available at www.springerlink.com)
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