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Footprints of intragenic recombination at HLA loci
https://ir.soken.ac.jp/records/3721
https://ir.soken.ac.jp/records/3721a8c1fac2-12b1-4a92-abec-ce455eb8b189
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-07-04 | |||||
| タイトル | ||||||
| タイトル | Footprints of intragenic recombination at HLA loci | |||||
| タイトル | ||||||
| タイトル | Footprints of intragenic recombination at HLA loci | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
TAKAHATA, Naoyuki
× TAKAHATA, Naoyuki× SATTA, Yoko |
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| 著者別名 |
尚之, 高畑
× 尚之, 高畑 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To evaluate the effect of balancing selection and intragenic recombination (or gene conversion) at six individual HLA loci, synonymous nucleotide diversity in different exon groups is examined within (πw) and between (πb) allelic lineages that may be defined by either serological or DNA sequence differences. Both π values are high in exons which encode for the peptide binding region (PBR) and tend to decrease in other exons. The value of πw is significantly smaller than that of πb in any exon of any locus. However, even πw is much greater than nucleotide diversity at non-HLA loci. These observations provide additional strong evidence for the operation of balancing selection in PBR-encoding exons and its indirect effects on polymorphism at linked neighboring regions. It appears that allelic lineages have generally evolved in isolation but the linkage relationships within and between exons are incomplete throughout the long evolutionary history. To quantify intragenic recombination and account for the large discrepancy between the HLA and non-HLA diversity, a population genetics model is analyzed with special reference to the evolution of modern humans. The analysis suggests that the recombination rate between two sites 1000 base pairs apart is about 10–5 per generation and that the effective size of human populations (equivalent roughly to the number of breeding individuals in a randomly mating population) has dropped from 105 to 104 in most of the Quaternary. One possibility for this reduction is discussed. | |||||
| 書誌情報 |
Immunogenetics en : Immunogenetics 巻 47, 号 6, p. 430-441, 発行日 1998 |
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| 出版者 | ||||||
| 出版者 | SpringerLink | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00937711 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 9553149 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://doi.org/10.1007/s002510050380 | |||||
| 関連名称 | 10.1007/s002510050380 | |||||
| 権利 | ||||||
| 権利情報 | SpringerLink(The original publication is available at www.springerlink.com) | |||||
