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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Molecular clock and recombination in primate Mhc genes

https://ir.soken.ac.jp/records/3724
https://ir.soken.ac.jp/records/3724
79833339-28bc-4f58-a84a-f84021e15a52
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-04
タイトル
タイトル Molecular clock and recombination in primate Mhc genes
タイトル
タイトル Molecular clock and recombination in primate Mhc genes
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

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KUPFERMANN, Heike

× KUPFERMANN, Heike

KUPFERMANN, Heike

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LI, Yi-Ju

× LI, Yi-Ju

LI, Yi-Ju

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 To set an accurate chronological framework to the evolution of primate class I and II genes in the major histocompatibility complex (Mhc), the rate of silent nucleotide substitutions in exons and introns is examined for various cDNA and genom sequences currently available. The rate is sensitive to the GC content and correlates negatively with increased GC biases at the third codon positions of Mhc genes. The intergenic recombination rate in the HLA region is estimated from the synonymous nucleotide differences at 37 linked loci. Any HLA subregion is recombined more or less at the ordinary rate of 1 cM per 1 Mb, although the rate may be reduced in some subregions. This information is used to discuss HLA haplotypes when they are applied to studies of human demography The unusual polymorphism in the α-helix of HLA-DRB1 is also revisited in relation to intragenic recombination, but the molecular mechanism and the evolutionary cause both remain enigmatic.
書誌情報 Immunological Reviews
en : Immunological Reviews

巻 167, p. 367-379, 発行日 1999
出版者
出版者 Wiley-Blackwell
ISSN
収録物識別子タイプ ISSN
収録物識別子 01052896
PubMed番号
識別子タイプ PMID
関連識別子 10319274
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1600-065X.1999.tb01405.x
関連名称 10.1111/j.1600-065X.1999.tb01405.x
権利
権利情報 © 1999–2013 John Wiley & Sons, Inc
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