| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-07-04 |
| タイトル |
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|
タイトル |
Molecular clock and recombination in primate Mhc genes |
| タイトル |
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タイトル |
Molecular clock and recombination in primate Mhc genes |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
SATTA, Yoko
KUPFERMANN, Heike
LI, Yi-Ju
TAKAHATA, Naoyuki
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
To set an accurate chronological framework to the evolution of primate class I and II genes in the major histocompatibility complex (Mhc), the rate of silent nucleotide substitutions in exons and introns is examined for various cDNA and genom sequences currently available. The rate is sensitive to the GC content and correlates negatively with increased GC biases at the third codon positions of Mhc genes. The intergenic recombination rate in the HLA region is estimated from the synonymous nucleotide differences at 37 linked loci. Any HLA subregion is recombined more or less at the ordinary rate of 1 cM per 1 Mb, although the rate may be reduced in some subregions. This information is used to discuss HLA haplotypes when they are applied to studies of human demography The unusual polymorphism in the α-helix of HLA-DRB1 is also revisited in relation to intragenic recombination, but the molecular mechanism and the evolutionary cause both remain enigmatic. |
| 書誌情報 |
Immunological Reviews
en : Immunological Reviews
巻 167,
p. 367-379,
発行日 1999
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| 出版者 |
|
|
出版者 |
Wiley-Blackwell |
| ISSN |
|
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
01052896 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
10319274 |
| DOI |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/j.1600-065X.1999.tb01405.x |
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|
関連名称 |
10.1111/j.1600-065X.1999.tb01405.x |
| 権利 |
|
|
権利情報 |
© 1999–2013 John Wiley & Sons, Inc |
