| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-07-04 |
| タイトル |
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タイトル |
Theoretical bases for karyotype evolution.II. The fusion burst in man and mouse. |
| タイトル |
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タイトル |
Theoretical bases for karyotype evolution.II. The fusion burst in man and mouse. |
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言語 |
en |
| 言語 |
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言語 |
jpn |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
IMAI, Hirotami T.
TAKAHATA, Naoyuki
MARUYAMA, Takeo
DANIEL, Art
HONDA, Takeo
MATSUDA, Yoichi
MORIWAKI, Kazuo
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
As a theoretical standard for evaluating the high incidence of centric fusion in man and mouse, the relative probabilities of occurrence of reciprocal translocation (Tr), inversion (In) and centric fusion (Fu) were estimated based on the random- contact-and-exchange model. It was shown by this model that centric fusion was extremely rare (Fu=0.0002, In=0.0521 and Tr=0.9477 for a human haploid karyotype). On the other hand, the occurrence rate of centric fusion in human newborn babies and European feral mice was about 500-1, 000 times higher than the theoretically expected values, which is termed here the "fusion burst". We suggest that the fusion burst may be induced by the physical proximity of telomeres on the nuclear membrane, and the exchange of DNA strands by errors of telomere replication mechanisms. The cytogenetical significance of the fusion burst is discussed with regard to the minimum interaction hypothesis proposed by Imai et al. (1986). We suggest two closely linked possibilities that (1) the fusion burst in man and mouse can theoretically be placed in karyotype evolution as a transitional phase in the main stream of the fission-inversion cycle, and (2) it may be accelerated by some unknown (mutagenic) factors other than ionizing radiation. |
| 書誌情報 |
Japanese Journal of Genetics
en : Japanese Journal of Genetics
巻 63,
号 4,
p. 313-342,
発行日 1988
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| 出版者 |
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出版者 |
The Genetics Society of Japan |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0021504X |
| PubMed番号 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
PMID |
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関連識別子 |
3078875 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1266/jjg.63.313 |
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関連名称 |
10.1266/jjg.63.313 |
| 権利 |
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権利情報 |
© 1993 by The Genetics Society of Japan |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://www.jstage.jst.go.jp/article/ggs1921/63/4/63_4_313/_article |
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関連名称 |
J-STAGE |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://www.jstage.jst.go.jp/pub/html/AY04S110_ja.html |
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関連名称 |
Copyright |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
4 (1.3 MB)
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