| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-07-04 |
| タイトル |
|
|
タイトル |
Evolution of Mhc-DRB introns: Implications for the origin of primates |
| タイトル |
|
|
タイトル |
Evolution of Mhc-DRB introns: Implications for the origin of primates |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
KUPFERMANN, Heike
SATTA, Yoko
TAKAHATA, Naoyuki
TICHY, Herbert
KLEIN, Jan
|
| 著者別名 |
尚之, 高畑
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Introns are generally believed to evolve too rapidly and too erratically to be of much use in phylogenetic reconstructions. Few phylogenetically informative intron sequences are available, however, to ascertain the validity of this supposition. In the present study the supposition was tested on the example of the mammalian class II major histocompatibility complex (Mhc) genes of the DRB family. Since the Mhc genes evolve under balancing selection and are believed to recombine or rearrange frequently, the evolution of their introns could be expected to be particularly rapid and subject to scrambling. Sequences of intron 4 and 5 DRB genes were obtained from polymerase chain reaction-amplified fragments of genomic DNA from representatives of six eutherian orders—Primates, Scandentia, Chiroptera, Dermoptera, Lagomorpha, and Insectivora. Although short stretches of the introns have indeed proved to be unalignable, the bulk of the intron sequences from all six orders, spanning >85 million years (my) of evolution, could be aligned and used in a study of the tempo and mode of intron evolution. The analysis has revealed the Mhc introns to evolve at a rate similar to that of other genes and of synonymous sites of non-Mhc genes. No evidence of homogenization or large-scale scrambling of the intron sequences could be found. The Mhc introns apparently evolve largely by point mutations and insertions/deletions. The phylogenetic signals contained in the intron sequences could be used to identify Scandentia as the sister group of Primates, to support the existence of the Archonta superorder, and to confirm the monophyly of the Chiroptera. |
| 書誌情報 |
Journal of Molecular Evolution
en : Journal of Molecular Evolution
巻 48,
号 6,
p. 663-674,
発行日 1999
|
| 出版者 |
|
|
出版者 |
SpringerLink |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00222844 |
| PubMed番号 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
10229570 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://doi.org/10.1007/PL00006510 |
|
|
関連名称 |
10.1007/PL00006510 |
| 権利 |
|
|
権利情報 |
SpringerLink(The original publication is available at www.springerlink.com) |
