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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Evolution of Mhc-DRB introns: Implications for the origin of primates

https://ir.soken.ac.jp/records/3734
https://ir.soken.ac.jp/records/3734
9381d930-7aef-465d-8548-7a5c709ac443
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-04
タイトル
タイトル Evolution of Mhc-DRB introns: Implications for the origin of primates
タイトル
言語 en
タイトル Evolution of Mhc-DRB introns: Implications for the origin of primates
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 KUPFERMANN, Heike

× KUPFERMANN, Heike

WEKO 1630

KUPFERMANN, Heike

Search repository
SATTA, Yoko

× SATTA, Yoko

WEKO 357

SATTA, Yoko

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

WEKO 778

TAKAHATA, Naoyuki

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TICHY, Herbert

× TICHY, Herbert

WEKO 1626

TICHY, Herbert

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KLEIN, Jan

× KLEIN, Jan

WEKO 1552

KLEIN, Jan

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著者別名 尚之, 高畑

× 尚之, 高畑

WEKO 1642

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 Introns are generally believed to evolve too rapidly and too erratically to be of much use in phylogenetic reconstructions. Few phylogenetically informative intron sequences are available, however, to ascertain the validity of this supposition. In the present study the supposition was tested on the example of the mammalian class II major histocompatibility complex (Mhc) genes of the DRB family. Since the Mhc genes evolve under balancing selection and are believed to recombine or rearrange frequently, the evolution of their introns could be expected to be particularly rapid and subject to scrambling. Sequences of intron 4 and 5 DRB genes were obtained from polymerase chain reaction-amplified fragments of genomic DNA from representatives of six eutherian orders—Primates, Scandentia, Chiroptera, Dermoptera, Lagomorpha, and Insectivora. Although short stretches of the introns have indeed proved to be unalignable, the bulk of the intron sequences from all six orders, spanning >85 million years (my) of evolution, could be aligned and used in a study of the tempo and mode of intron evolution. The analysis has revealed the Mhc introns to evolve at a rate similar to that of other genes and of synonymous sites of non-Mhc genes. No evidence of homogenization or large-scale scrambling of the intron sequences could be found. The Mhc introns apparently evolve largely by point mutations and insertions/deletions. The phylogenetic signals contained in the intron sequences could be used to identify Scandentia as the sister group of Primates, to support the existence of the Archonta superorder, and to confirm the monophyly of the Chiroptera.
書誌情報 Journal of Molecular Evolution
en : Journal of Molecular Evolution

巻 48, 号 6, p. 663-674, 発行日 1999
出版者
出版者 SpringerLink
ISSN
収録物識別子タイプ ISSN
収録物識別子 00222844
PubMed番号
識別子タイプ PMID
関連識別子 10229570
DOI
識別子タイプ DOI
関連識別子 http://doi.org/10.1007/PL00006510
関連名称 10.1007/PL00006510
権利
権利情報 SpringerLink(The original publication is available at www.springerlink.com)
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