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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Evolution of hominoid mitochondrial DNA with special reference to the silent substitution rate over the genome

https://ir.soken.ac.jp/records/3736
https://ir.soken.ac.jp/records/3736
f2574624-dbb6-4265-824c-ade8345b5e1b
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-04
タイトル
タイトル Evolution of hominoid mitochondrial DNA with special reference to the silent substitution rate over the genome
タイトル
タイトル Evolution of hominoid mitochondrial DNA with special reference to the silent substitution rate over the genome
言語 en
言語
言語 jpn
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 KONDO, Rumi

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KONDO, Rumi

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HORAI, Satoshi

× HORAI, Satoshi

HORAI, Satoshi

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SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 Focusing on the synonymous substitution rate, we carried out detailed sequence analyses of hominoid mitochondrial (mt) DNAs of ca. 5-kb length. Owing to the outnumbered transitions and strong biases in the base compositions, synonymous substitutions in mtDNA reach rapidly a rather low saturation level. The extent of the compositional biases differs from gene to gene. Such changes in base compositions, even if small, can bring about considerable variation in observed synonymous differences and may result in the region-dependent estimate of the synonymous substitution rate. We demonstrate that such a region dependency is due to a failure to take proper account of heterogeneous compositional biases from gene to gene but that the actual synonymous substitution rate is rather uniform. The synonymous substitution rate thus estimated is 2.37 ± 0.11 × 10−8 per site per year and comparable to the overall rate for the noncoding region. On the other hand, the rate of nonsynonymous substitutions differs considerably from gene to gene, as expected under the neutral theory of molecular evolution. The lowest rate is 0.8 × 10−9 per site per year forCOI and the highest rate is 4.5 × 10−9 forATPase 8, the degree of functional constraints (measured by the ratio of the nonsynonymous to the synonymous substitution rate) being 0.03 and 0.19, respectively. Transfer RNA (tRNA) genes also show variability in the base contents and thus in the nucleotide differences. The average rate for 11 tRNAs contained in the 5-kb region is 3.9 × 10−9 per site per year. The nucleotide substitutions in the genome suggest that the transition rate is about 17 times faster than the transversion rate.
書誌情報 Journal of Molecular Evolution
en : Journal of Molecular Evolution

巻 36, 号 6, p. 517-531, 発行日 1993
出版者
出版者 SpringerLink
ISSN
収録物識別子タイプ ISSN
収録物識別子 00222844
PubMed番号
識別子タイプ PMID
関連識別子 8394433
DOI
識別子タイプ DOI
関連識別子 http://doi.org/10.1007/BF00556356
関連名称 10.1007/BF00556356
権利
権利情報 SpringerLink(The original publication is available at www.springerlink.com)
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