Allelic genealogy and human evolution

尚之, 高畑; TAKAHATA, Naoyuki

doi:https://doi.org/10.1093/oxfordjournals.molbev.a039995

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Allelic genealogy and human evolution

https://ir.soken.ac.jp/records/3753

Item type

学術雑誌論文 / Journal Article(1)

公開日

2013-07-08

タイトル

Allelic genealogy and human evolution

タイトル

Allelic genealogy and human evolution

言語

eng

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資源タイプ識別子

http://purl.org/coar/resource_type/c_6501

資源タイプ

journal article

アクセス権

metadata only access

アクセス権URI

http://purl.org/coar/access_right/c_14cb

著者

TAKAHATA, Naoyuki

著者別名

尚之, 高畑

抄録

内容記述タイプ

Abstract

内容記述

Genetic variation at most loci examined in human populations indicates that the (effective) population size has been ~104 for the past 1 Myr and that individuals have been genetically united rather tightly. Also suggested is that the population size has never dropped to a few individuals, even in a single generation. These impose important requirements for the hypotheses for the origin of modern humans: a relatively large population size and frequent migration if populations were geographically subdivided. Any hypothesis that assumes a small number of founding individuals throughout the late Pleistocene can be rejected. Extraordinary polymorphism at some loci of the major histocompatibility complex (Mhc) rules out the past action of severe bottlenecks, or the so-called founder principle, which invokes only a small number of founding individuals when a new species emerges. This conclusion may be extended to the 35-Myr-old history of the human lineage, because some polymorphism at Mhc loci seems to have lasted that long. Furthermore, although the population structure prior to the late Pleistocene is less clear, owing to the insensitivity of Mhc alleles, even to low levels of migration, the nature of Mhc polymorphism suggests that the effective size of populations leading to humans was as large as 105. Hence, the effective population size of humans might have become somewhat smaller in most of the late Pleistocene. The reduction could be due either to the then adverse environment in the Old World and/or to the increased migration rate. It is also argued that population explosion fostered by the agriculture revolution has had significant effects on incorporating new alleles into human populations.

書誌情報

Molecular Biology and Evolution
en : Molecular Biology and Evolution

巻 10, 号 1, p. 2-22, 発行日 1993

出版者

Oxford University Press

ISSN

収録物識別子タイプ

ISSN

収録物識別子

07374038

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PMID

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2023-06-20 14:30:42.894131

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Allelic genealogy and human evolution

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× 尚之, 高畑

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