| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-07-08 |
| タイトル |
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|
タイトル |
Divergence, demography and gene loss along the human lineage |
| タイトル |
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タイトル |
Divergence, demography and gene loss along the human lineage |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
KIM, HieLim
IGAWA, Takeshi
KAWASHIMA, Ayaka
SATTA, Yoko
TAKAHATA, Naoyuki
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Genomic DNA sequences are an irreplaceable source for reconstructing the vanished past of living organisms. Based on updated sequence data, this paper summarizes our studies on species divergence time, ancient population size and functional loss of genes in the primate lineage leading to modern humans (Homo sapiens sapiens). The inter-and intraspecific comparisons of DNA sequences suggest that the human lineage experienced a rather severe bottleneck in the Middle Pleistocene, throughout which period the subdivided African population played a predominant role in shaping the genetic architecture of modern humans. Also, published and newly identified human-specific pseudogenes (HSPs) are enumerated in order to infer their significance for human evolution. Of the 121 candidate genes obtained, authentic HSPs turn out to comprise only 25 olfactory receptor genes, four T cell receptor genes and nine other genes. The fixation of HSPs has been too rare over the past 6-7 Myr to account for species differences between humans and chimpanzees. |
| 書誌情報 |
Philosophical Transactions of the Royal Society B: Biological Sciences
en : Philosophical Transactions of the Royal Society B: Biological Sciences
巻 365,
号 1552,
p. 2451-2457,
発行日 2010-08
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| 出版者 |
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出版者 |
The Royal Society Publishing |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
09628436 |
| PubMed番号 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
PMID |
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関連識別子 |
20643734 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1098/rstb.2010.0004 |
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関連名称 |
10.1098/rstb.2010.0004 |
| 権利 |
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|
権利情報 |
© 2010 The Royal Society |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
2451.full (219.5 kB)
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