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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution

https://ir.soken.ac.jp/records/3760
https://ir.soken.ac.jp/records/3760
2c45a39c-4e87-46c6-9189-f0ca0166c69a
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-08
タイトル
タイトル Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution
タイトル
言語 en
タイトル Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 CHOU, Hsun-Hua

× CHOU, Hsun-Hua

WEKO 1668

CHOU, Hsun-Hua

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HAYAKAWA, Toshiyuki

× HAYAKAWA, Toshiyuki

WEKO 1563

HAYAKAWA, Toshiyuki

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DIAZ, Sandra

× DIAZ, Sandra

WEKO 1669

DIAZ, Sandra

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KRINGS, Matthias

× KRINGS, Matthias

WEKO 1670

KRINGS, Matthias

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INDRIATI, Etty

× INDRIATI, Etty

WEKO 1671

INDRIATI, Etty

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LEAKEY, Meave

× LEAKEY, Meave

WEKO 1672

LEAKEY, Meave

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PAABO, Svante

× PAABO, Svante

WEKO 1673

PAABO, Svante

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SATTA, Yoko

× SATTA, Yoko

WEKO 357

SATTA, Yoko

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

WEKO 778

TAKAHATA, Naoyuki

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VARKI, Ajit

× VARKI, Ajit

WEKO 1600

VARKI, Ajit

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著者別名 尚之, 高畑

× 尚之, 高畑

WEKO 1577
NRID 1000030124217
e-Rad 30124217

尚之, 高畑

Search repository
抄録
内容記述タイプ Abstract
内容記述 Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu-mediated inactivating mutation of the gene encoding the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase (CMAH). This mutation occurred after our last common ancestor with bonobos and chimpanzees, and before the origin of present-day humans. Here, we take multiple approaches to estimate the timing of this mutation in relationship to human evolutionary history. First, we have developed a method to extract and identify sialic acids from bones and bony fossils. Two Neandertal fossils studied had clearly detectable Neu5Ac but no Neu5Gc, indicating that the CMAH mutation predated the common ancestor of humans and Neandertals, ≈0.5-0.6 million years ago (mya). Second, we date the insertion event of the inactivating human-specific sahAluY element that replaced the ancestral AluSq element found adjacent to exon 6 of the CMAH gene in the chimpanzee genome. Assuming Alu source genes based on a phylogenetic tree of human-specific Alu elements, we estimate the sahAluY insertion time at ≈2.7 mya. Third, we apply molecular clock analysis to chimpanzee and other great ape CMAH genes and the corresponding human pseudogene to estimate an inactivation time of ≈2.8 mya. Taken together, these studies indicate that the CMAH gene was inactivated shortly before the time when brain expansion began in humankind's ancestry, ≈2.1-2.2 mya. In this regard, it is of interest that although Neu5Gc is the major sialic acid in most organs of the chimpanzee, its expression is selectively down-regulated in the brain, for as yet unknown reasons.
書誌情報 Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America

巻 99, 号 18, p. 11736-11741, 発行日 2002-09-03
出版者
出版者 National Academy of Sciences
ISSN
収録物識別子タイプ ISSN
収録物識別子 10916490
PubMed番号
識別子タイプ PMID
関連識別子 12192086
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1073/pnas.182257399
関連名称 10.1073/pnas.182257399
権利
権利情報 © 2002, The National Academy of Sciences
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