| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-07-08 |
| タイトル |
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タイトル |
Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs |
| タイトル |
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タイトル |
Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
HORAI, Satoshi
HAYASAKA, Kenji
KONDO, Rumi
TSUGANE, Kazuo
TAKAHATA, Naoyuki
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
We analyzed the complete mitochondrial DNA (mtDNA) sequences of three humans (African, European, and Japanese), three African apes (common and pygmy chimpanzees, and gorilla), and one orangutan in an attempt to estimate most accurately the substitution rates and divergence times of hominoid mtDNAs. Nonsynonymous substitutions and substitutions in RNA genes have accumulated with an approximately clock-like regularity. From these substitutions and under the assumption that the orangutan and African apes diverged 13 million years ago, we obtained a divergence time for humans and chimpanzees of 4.9 million years. This divergence time permitted calibration of the synonymous substitution rate (3.89 x 10(-8)/site per year). To obtain the substitution rate in the displacement (D)-loop region, we compared the three human mtDNAs and measured the relative abundance of substitutions in the D-loop region and at synonymous sites. The estimated substitution rate in the D-loop region was 7.00 x 10(-8)/site per year. Using both synonymous and D-loop substitutions, we inferred the age of the last common ancestor of the human mtDNAs as 143,000 +/- 18,000 years. The shallow ancestry of human mtDNAs, together with the observation that the African sequence is the most diverged among humans, strongly supports the recent African origin of modern humans, Homo sapiens sapiens. |
| 書誌情報 |
Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America
巻 92,
号 2,
p. 532-536,
発行日 1995-01-17
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| 出版者 |
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出版者 |
National Academy of Sciences |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
10916490 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
7530363 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1073/pnas.92.2.532 |
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関連名称 |
10.1073/pnas.92.2.532 |
| 権利 |
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権利情報 |
© National Academy of Sciences |
