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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Evolution of the mouse t haplotype: Recent and worldwide introgression to Mus musculus

https://ir.soken.ac.jp/records/3766
https://ir.soken.ac.jp/records/3766
b49f1a52-258f-474b-a6d0-17fa7e0b2736
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-09
タイトル
タイトル Evolution of the mouse t haplotype: Recent and worldwide introgression to Mus musculus
タイトル
タイトル Evolution of the mouse t haplotype: Recent and worldwide introgression to Mus musculus
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 MORITA, Takashi

× MORITA, Takashi

MORITA, Takashi

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KUBOTA, Hiroshi

× KUBOTA, Hiroshi

KUBOTA, Hiroshi

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MURATA, Keiko

× MURATA, Keiko

MURATA, Keiko

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NOZAKI, Masami

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NOZAKI, Masami

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DELARBRE, Christiane

× DELARBRE, Christiane

DELARBRE, Christiane

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WILLISON, Keith R.

× WILLISON, Keith R.

WILLISON, Keith R.

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SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

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SAKAIZUMI, Mitsuru

× SAKAIZUMI, Mitsuru

SAKAIZUMI, Mitsuru

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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GACHELIN, Gabriel

× GACHELIN, Gabriel

GACHELIN, Gabriel

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MATSUSHIRO, Aizo

× MATSUSHIRO, Aizo

MATSUSHIRO, Aizo

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著者別名 尚之, 高畑

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尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 Mouse t haplotypes are variants of chromosome 17, consisting of four inversions. Despite the homozygous lethality and pleiotropic effect on embryonic development, sperm production, and recombination, they have widely spread in natural populations of the house mouse (10-40% in frequency) because of the meiotic drive advantage. We sequenced 14 Tcp-1 (t-complex polypeptide 1) genes from four t haplotypes, nine wild mice, and a rat as a reference. From a comparison of intron sequences of 610 base pairs, we dated the origin of t haplotypes to 2.9 ± 0.7 million years ago, which predates the splitting of Mus musculus subspecies (≈1 million years ago). However, the Tcp-1 intron sequences of t haplotypes from different M. musculus subspecies from various parts of the world show no divergence, indicating the recent introgression (no earlier than 0.8 million years ago) of a single ancestral type. Nucleotide changes in coding regions are also consistent with this conclusion. Hence, polymorphisms among t haplotypes including lethality factors have accumulated during this short time period independently in each M. musculus subspecies.
書誌情報 Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America

巻 89, 号 15, p. 6851-6855, 発行日 1992
出版者
出版者 National Academy of Sciences
ISSN
収録物識別子タイプ ISSN
収録物識別子 10916490
PubMed番号
識別子タイプ PMID
関連識別子 1495973
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1073/pnas.89.15.6851
関連名称 10.1073/pnas.89.15.6851
権利
権利情報 © National Academy of Sciences
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