| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-07-09 |
| タイトル |
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タイトル |
Evolution of the mouse t haplotype: Recent and worldwide introgression to Mus musculus |
| タイトル |
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タイトル |
Evolution of the mouse t haplotype: Recent and worldwide introgression to Mus musculus |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
MORITA, Takashi
KUBOTA, Hiroshi
MURATA, Keiko
NOZAKI, Masami
DELARBRE, Christiane
WILLISON, Keith R.
SATTA, Yoko
SAKAIZUMI, Mitsuru
TAKAHATA, Naoyuki
GACHELIN, Gabriel
MATSUSHIRO, Aizo
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Mouse t haplotypes are variants of chromosome 17, consisting of four inversions. Despite the homozygous lethality and pleiotropic effect on embryonic development, sperm production, and recombination, they have widely spread in natural populations of the house mouse (10-40% in frequency) because of the meiotic drive advantage. We sequenced 14 Tcp-1 (t-complex polypeptide 1) genes from four t haplotypes, nine wild mice, and a rat as a reference. From a comparison of intron sequences of 610 base pairs, we dated the origin of t haplotypes to 2.9 ± 0.7 million years ago, which predates the splitting of Mus musculus subspecies (≈1 million years ago). However, the Tcp-1 intron sequences of t haplotypes from different M. musculus subspecies from various parts of the world show no divergence, indicating the recent introgression (no earlier than 0.8 million years ago) of a single ancestral type. Nucleotide changes in coding regions are also consistent with this conclusion. Hence, polymorphisms among t haplotypes including lethality factors have accumulated during this short time period independently in each M. musculus subspecies. |
| 書誌情報 |
Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America
巻 89,
号 15,
p. 6851-6855,
発行日 1992
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| 出版者 |
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出版者 |
National Academy of Sciences |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
10916490 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
1495973 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1073/pnas.89.15.6851 |
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関連名称 |
10.1073/pnas.89.15.6851 |
| 権利 |
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権利情報 |
© National Academy of Sciences |
