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  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

A simple genealogical structure of strongly balanced allelic lines and trans-species evolution of polymorphism

https://ir.soken.ac.jp/records/3767
https://ir.soken.ac.jp/records/3767
978e5f60-71f5-4749-b1f6-6038325e5393
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-09
タイトル
タイトル A simple genealogical structure of strongly balanced allelic lines and trans-species evolution of polymorphism
タイトル
言語 en
タイトル A simple genealogical structure of strongly balanced allelic lines and trans-species evolution of polymorphism
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

WEKO 778

TAKAHATA, Naoyuki

Search repository
著者別名 尚之, 高畑

× 尚之, 高畑

WEKO 1577
NRID 1000030124217
e-Rad 30124217

尚之, 高畑

Search repository
抄録
内容記述タイプ Abstract
内容記述 Different alleles undergoing strong symmetric balancing selection show a simple genealogical structure (allelic genealogy), similar to the gene genealogy described by the coalescence process for a sample of neutral genes randomly drawn from a panmictic population at equilibrium. The only difference between the two genealogies lies in the different time scales. An approximate scaling factor for allelic genealogy relative to that of neutral gene genealogy is {√S/(2M)} · [In{S/(16πM2)}](-3/2), where M = Nu and S = 2Ns (N, effective population size; u, mutation rate to selected alleles per locus per generation; s, selection coefficient). The larger the value of √S/M (≥ 100), the larger the scaling factor. These findings, supported by simulation results, allow one to apply the theoretical results of the coalescence process directly to the allelic genealogy. Combined with the trans-species evolution of the major histocompatibility complex polymorphism for which balancing selection is believed to be responsible, allelic genealogy predicts that the number of breeding individuals in the human population could not be as small as 50-100 at any time of its evolutionary history. The analysis appears to contradict the found principle as being important in recent mammalian evolution.
書誌情報 Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America

巻 87, 号 7, p. 2419-2423, 発行日 1990
出版者
出版者 National Academy of Sciences
ISSN
収録物識別子タイプ ISSN
収録物識別子 10916490
PubMed番号
識別子タイプ PMID
関連識別子 2320564
権利
権利情報 © National Academy of Sciences
関連サイト
識別子タイプ URI
関連識別子 https://www.pnas.org/content/87/7/2419/tab-article-info
関連名称 National Academy of Sciences
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