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A simple genealogical structure of strongly balanced allelic lines and trans-species evolution of polymorphism
https://ir.soken.ac.jp/records/3767
https://ir.soken.ac.jp/records/3767978e5f60-71f5-4749-b1f6-6038325e5393
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2013-07-09 | |||||||
| タイトル | ||||||||
| タイトル | A simple genealogical structure of strongly balanced allelic lines and trans-species evolution of polymorphism | |||||||
| タイトル | ||||||||
| タイトル | A simple genealogical structure of strongly balanced allelic lines and trans-species evolution of polymorphism | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| アクセス権 | ||||||||
| アクセス権 | metadata only access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||
| 著者 |
TAKAHATA, Naoyuki
× TAKAHATA, Naoyuki
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| 著者別名 |
尚之, 高畑
× 尚之, 高畑
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Different alleles undergoing strong symmetric balancing selection show a simple genealogical structure (allelic genealogy), similar to the gene genealogy described by the coalescence process for a sample of neutral genes randomly drawn from a panmictic population at equilibrium. The only difference between the two genealogies lies in the different time scales. An approximate scaling factor for allelic genealogy relative to that of neutral gene genealogy is {√S/(2M)} · [In{S/(16πM2)}](-3/2), where M = Nu and S = 2Ns (N, effective population size; u, mutation rate to selected alleles per locus per generation; s, selection coefficient). The larger the value of √S/M (≥ 100), the larger the scaling factor. These findings, supported by simulation results, allow one to apply the theoretical results of the coalescence process directly to the allelic genealogy. Combined with the trans-species evolution of the major histocompatibility complex polymorphism for which balancing selection is believed to be responsible, allelic genealogy predicts that the number of breeding individuals in the human population could not be as small as 50-100 at any time of its evolutionary history. The analysis appears to contradict the found principle as being important in recent mammalian evolution. | |||||||
| 書誌情報 |
Proceedings of the National Academy of Sciences of the United States of America en : Proceedings of the National Academy of Sciences of the United States of America 巻 87, 号 7, p. 2419-2423, 発行日 1990 |
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| 出版者 | ||||||||
| 出版者 | National Academy of Sciences | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 10916490 | |||||||
| PubMed番号 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 2320564 | |||||||
| 権利 | ||||||||
| 権利情報 | © National Academy of Sciences | |||||||
| 関連サイト | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.pnas.org/content/87/7/2419/tab-article-info | |||||||
| 関連名称 | National Academy of Sciences | |||||||
