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  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Genetic variability maintained in a finite population under mutation and autocorrelated random fluctuation of selection intensity

https://ir.soken.ac.jp/records/3770
https://ir.soken.ac.jp/records/3770
91355c8b-b27d-489c-b045-642d59a576f3
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-09
タイトル
タイトル Genetic variability maintained in a finite population under mutation and autocorrelated random fluctuation of selection intensity
タイトル
タイトル Genetic variability maintained in a finite population under mutation and autocorrelated random fluctuation of selection intensity
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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KIMURA, Motoo

× KIMURA, Motoo

KIMURA, Motoo

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 By using the diffusion equation method, the level of genetic variability maintained under mutation pressure in a finite population is investigated, assuming autocorrelated random fluctation of selection intensity. An appropriate mathematical model was formulated to treat the change of gene frequencies, incorporating mutation pressure and fluctuating selection. Extensive Monte Carlo simulation experiments were also performed to supplement the theoretical treatments. Excellent agreement between the two results suggests the validity of the present diffusion model for the autocorrelated selection. One of the most important findings from the simulation studies is that mutations and random sampling drift largely determine the level of genetic variability, and that the presence of autocorrelated selection can significantly lower genetic variability only when its strength, as measured by the cumulative variance of selection intensity, is larger than about 103 times the mutation rate. It is pointed out that the effects of both mutations and random sampling drift have to be incorporated in order to assess the role of various factors for the maintenance of genetic variability in natural populations.
書誌情報 Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America

巻 76, 号 11, p. 5813-5817, 発行日 1979
出版者
出版者 National Academy of Sciences
ISSN
収録物識別子タイプ ISSN
収録物識別子 10916490
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1073/pnas.76.11.5813
関連名称 10.1073/pnas.76.11.5813
権利
権利情報 © National Academy of Sciences
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