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  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Polymorphism and loss of duplicate gene expression: A theoretical study with application to tetraploid fish

https://ir.soken.ac.jp/records/3771
https://ir.soken.ac.jp/records/3771
ca114bed-3944-4e82-b2e2-39a720b91595
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-09
タイトル
タイトル Polymorphism and loss of duplicate gene expression: A theoretical study with application to tetraploid fish
タイトル
タイトル Polymorphism and loss of duplicate gene expression: A theoretical study with application to tetraploid fish
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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MARUYAMA, Takeo

× MARUYAMA, Takeo

MARUYAMA, Takeo

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 We studied the fixation of null alleles at independent duplicate loci, assuming that wild-type active alleles mutate irreversibly to nonfunctional null alleles and that the population is finite and panmictic. Solving the two-dimensional Kolmogorov backward equation numerically, we obtained the rate at which one of the active genes is lost and the amount of heterozygosity at specified times. Previously harmful genes, including recessive lethals, can be fixed at one of the duplicate loci, which would not happen with a single locus. Examination of data from several fish families showed that the rate of fixation of null alleles is too slow and the amount of heterozygosity too small to be compatible with complete recessivity at all loci. Our conclusion differs in this regard from that of Bailey et al. They also reported that the time taken for 50% of the loci to be fixed for null alleles is approximately 15N + v-(3/4), in which N and v are the effective population size and mutation rate, when the alleles are completely recessive and the double homozygote is lethal. We found that the fixation rate depends not only on N, but also on Nv.
書誌情報 Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America

巻 76, 号 9, p. 4521-4525, 発行日 1979
出版者
出版者 National Academy of Sciences
ISSN
収録物識別子タイプ ISSN
収録物識別子 10916490
PubMed番号
識別子タイプ PMID
関連識別子 291985
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1073/pnas.76.9.4521
関連名称 10.1073/pnas.76.9.4521
権利
権利情報 © National Academy of Sciences
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