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Polymorphism and loss of duplicate gene expression: A theoretical study with application to tetraploid fish
https://ir.soken.ac.jp/records/3771
https://ir.soken.ac.jp/records/3771ca114bed-3944-4e82-b2e2-39a720b91595
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2013-07-09 | |||||||||
| タイトル | ||||||||||
| タイトル | Polymorphism and loss of duplicate gene expression: A theoretical study with application to tetraploid fish | |||||||||
| タイトル | ||||||||||
| タイトル | Polymorphism and loss of duplicate gene expression: A theoretical study with application to tetraploid fish | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | metadata only access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||
| 著者 |
TAKAHATA, Naoyuki
× TAKAHATA, Naoyuki
× MARUYAMA, Takeo
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| 著者別名 |
尚之, 高畑
× 尚之, 高畑
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | We studied the fixation of null alleles at independent duplicate loci, assuming that wild-type active alleles mutate irreversibly to nonfunctional null alleles and that the population is finite and panmictic. Solving the two-dimensional Kolmogorov backward equation numerically, we obtained the rate at which one of the active genes is lost and the amount of heterozygosity at specified times. Previously harmful genes, including recessive lethals, can be fixed at one of the duplicate loci, which would not happen with a single locus. Examination of data from several fish families showed that the rate of fixation of null alleles is too slow and the amount of heterozygosity too small to be compatible with complete recessivity at all loci. Our conclusion differs in this regard from that of Bailey et al. They also reported that the time taken for 50% of the loci to be fixed for null alleles is approximately 15N + v-(3/4), in which N and v are the effective population size and mutation rate, when the alleles are completely recessive and the double homozygote is lethal. We found that the fixation rate depends not only on N, but also on Nv. | |||||||||
| 書誌情報 |
Proceedings of the National Academy of Sciences of the United States of America en : Proceedings of the National Academy of Sciences of the United States of America 巻 76, 号 9, p. 4521-4525, 発行日 1979 |
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| 出版者 | ||||||||||
| 出版者 | National Academy of Sciences | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 10916490 | |||||||||
| PubMed番号 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 291985 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1073/pnas.76.9.4521 | |||||||||
| 関連名称 | 10.1073/pnas.76.9.4521 | |||||||||
| 権利 | ||||||||||
| 権利情報 | © National Academy of Sciences | |||||||||
