Overdispersed molecular clock at the major histocompatibility complex loci

尚之, 高畑; TAKAHATA, Naoyuki

doi:https://doi.org/10.1098/rspb.1991.0003

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Overdispersed molecular clock at the major histocompatibility complex loci

https://ir.soken.ac.jp/records/3775

Item type

学術雑誌論文 / Journal Article(1)

公開日

2013-07-09

タイトル

Overdispersed molecular clock at the major histocompatibility complex loci

タイトル

Overdispersed molecular clock at the major histocompatibility complex loci

言語

eng

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資源タイプ識別子

http://purl.org/coar/resource_type/c_6501

資源タイプ

journal article

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metadata only access

アクセス権URI

http://purl.org/coar/access_right/c_14cb

著者

TAKAHATA, Naoyuki

著者別名

尚之, 高畑

抄録

内容記述タイプ

Abstract

内容記述

The extent of amino acid differences of major histocompatibility complex molecules within species is unusually high, consistent with the finding that some pairs of alleles have persisted for more than ten million years and the view that the polymorphism has been maintained by natural selection. The disparity between synonymous and non-synonymous substitutions in the antigen recognition site, however, suggests that some non-synonymous sites have undergone a number of substitutions whereas others have little or none. To describe statistically such an overdispersed underlying process, commonly used Poisson processes are inadequate. An alternative process leads to the surprising conclusion that each non-synonymous site has accumulated as many as 2.b substitutions, on the average, in the two lineages leading to humans and mice. The standard deviation is also very large (0.0) and the dispersion index (the ratio of the variance to the mean) is at least 17. The substitution process thus inferred qualitatively agrees with the disposition (a boomerang pattern) of substitutions between HLA-A2 and Aw08 alleles, and quantitatively agrees well with that expected where the evolution of major histocompatibility complex molecules has long been driven mostly by balancing selection.

書誌情報

Proceedings of the Royal Society B: Biological Sciences
en : Proceedings of the Royal Society B: Biological Sciences

巻 243, 号 1306, p. 13-18, 発行日 1991

出版者

The Royal Society Publishing

ISSN

収録物識別子タイプ

ISSN

収録物識別子

09628452

PubMed番号

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PMID

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2023-06-20 14:30:28.180383

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Overdispersed molecular clock at the major histocompatibility complex loci

× TAKAHATA, Naoyuki

× 尚之, 高畑

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