WEKO3
アイテム
Overdispersed molecular clock at the major histocompatibility complex loci
https://ir.soken.ac.jp/records/3775
https://ir.soken.ac.jp/records/37757fc8a0bc-85ff-45e6-b989-efdacf8f392d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-07-09 | |||||
| タイトル | ||||||
| タイトル | Overdispersed molecular clock at the major histocompatibility complex loci | |||||
| タイトル | ||||||
| タイトル | Overdispersed molecular clock at the major histocompatibility complex loci | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
TAKAHATA, Naoyuki
× TAKAHATA, Naoyuki |
|||||
| 著者別名 |
尚之, 高畑
× 尚之, 高畑 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The extent of amino acid differences of major histocompatibility complex molecules within species is unusually high, consistent with the finding that some pairs of alleles have persisted for more than ten million years and the view that the polymorphism has been maintained by natural selection. The disparity between synonymous and non-synonymous substitutions in the antigen recognition site, however, suggests that some non-synonymous sites have undergone a number of substitutions whereas others have little or none. To describe statistically such an overdispersed underlying process, commonly used Poisson processes are inadequate. An alternative process leads to the surprising conclusion that each non-synonymous site has accumulated as many as 2.b substitutions, on the average, in the two lineages leading to humans and mice. The standard deviation is also very large (0.0) and the dispersion index (the ratio of the variance to the mean) is at least 17. The substitution process thus inferred qualitatively agrees with the disposition (a boomerang pattern) of substitutions between HLA-A2 and Aw08 alleles, and quantitatively agrees well with that expected where the evolution of major histocompatibility complex molecules has long been driven mostly by balancing selection. | |||||
| 書誌情報 |
Proceedings of the Royal Society B: Biological Sciences en : Proceedings of the Royal Society B: Biological Sciences 巻 243, 号 1306, p. 13-18, 発行日 1991 |
|||||
| 出版者 | ||||||
| 出版者 | The Royal Society Publishing | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09628452 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 1673240 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1098/rspb.1991.0003 | |||||
| 関連名称 | 10.1098/rspb.1991.0003 | |||||
| 権利 | ||||||
| 権利情報 | © The Royal Society | |||||
