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  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Overdispersed molecular clock at the major histocompatibility complex loci

https://ir.soken.ac.jp/records/3775
https://ir.soken.ac.jp/records/3775
7fc8a0bc-85ff-45e6-b989-efdacf8f392d
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-09
タイトル
タイトル Overdispersed molecular clock at the major histocompatibility complex loci
タイトル
タイトル Overdispersed molecular clock at the major histocompatibility complex loci
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 The extent of amino acid differences of major histocompatibility complex molecules within species is unusually high, consistent with the finding that some pairs of alleles have persisted for more than ten million years and the view that the polymorphism has been maintained by natural selection. The disparity between synonymous and non-synonymous substitutions in the antigen recognition site, however, suggests that some non-synonymous sites have undergone a number of substitutions whereas others have little or none. To describe statistically such an overdispersed underlying process, commonly used Poisson processes are inadequate. An alternative process leads to the surprising conclusion that each non-synonymous site has accumulated as many as 2.b substitutions, on the average, in the two lineages leading to humans and mice. The standard deviation is also very large (0.0) and the dispersion index (the ratio of the variance to the mean) is at least 17. The substitution process thus inferred qualitatively agrees with the disposition (a boomerang pattern) of substitutions between HLA-A2 and Aw08 alleles, and quantitatively agrees well with that expected where the evolution of major histocompatibility complex molecules has long been driven mostly by balancing selection.
書誌情報 Proceedings of the Royal Society B: Biological Sciences
en : Proceedings of the Royal Society B: Biological Sciences

巻 243, 号 1306, p. 13-18, 発行日 1991
出版者
出版者 The Royal Society Publishing
ISSN
収録物識別子タイプ ISSN
収録物識別子 09628452
PubMed番号
識別子タイプ PMID
関連識別子 1673240
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1098/rspb.1991.0003
関連名称 10.1098/rspb.1991.0003
権利
権利情報 © The Royal Society
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