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Sexual recombination under the joint effects of mutation, selection, and random sampling drift
https://ir.soken.ac.jp/records/3785
https://ir.soken.ac.jp/records/3785028a9ceb-565b-47aa-8240-a8780c2e05c4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2013-07-09 | |||||||
| タイトル | ||||||||
| タイトル | Sexual recombination under the joint effects of mutation, selection, and random sampling drift | |||||||
| タイトル | ||||||||
| タイトル | Sexual recombination under the joint effects of mutation, selection, and random sampling drift | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| アクセス権 | ||||||||
| アクセス権 | metadata only access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||
| 著者 |
TAKAHATA, Naoyuki
× TAKAHATA, Naoyuki
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| 著者別名 |
尚之, 高畑
× 尚之, 高畑
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The advantage or disadvantage of sexual reproduction or recombination for the accumulation of mutant genes in a population is studied under the joint effects of recurrent mutations, selection, and random sampling drift. To obtain the rate at which mutant genes are incorporated three different methods are used; numerical integration of Kolmogorov backward equations, simulation of stochastic difference equations, and Monte Carlo experiments. The first two methods are used in a two-locus system to obtain the fixation probability of double mutants and other related quantities under five different selection models. The third one is conducted for a multiple-locus system and the rate of accumulation of mutant genes per locus is studied. Comparison of the results between sexual and asexual populations shows that the effect of recombination depends on initial linkage disequilibrium, mutation rate v, selection intensity s, and population size Ne. The mode of selection is also an important factor and the large effect of recombination is observed when mutant genes are individually deleterious but collectively favorable. Under a given model of selection, the great advantage or disadvantage of recombination is achieved when a large extent of genetic polymorphism is produced not by mutation but by recombination. Extreme values of Nes and Nev make the effect insignificant. The results of Monte Carlo experiments also reveal the presence of interaction between selection and sampling drift even when the loci segregate independently and selection is multiplicative. Although this interaction is usually small, there are cases in which one locus theory cannot be used freely. In those cases, the effect of recombination is prominent and one locus theory gives an overestimate of the rate. | |||||||
| 書誌情報 |
Theoretical Population Biology en : Theoretical Population Biology 巻 22, 号 2, p. 258-277, 発行日 1982-10 |
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| 出版者 | ||||||||
| 出版者 | Elsevier | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 00405809 | |||||||
| PubMed番号 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 7179169 | |||||||
| DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1016/0040-5809(82)90045-4 | |||||||
| 関連名称 | 10.1016/0040-5809(82)90045-4 | |||||||
| 権利 | ||||||||
| 権利情報 | © 1982 Published by Elsevier Inc. | |||||||
