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  1. 010 学術雑誌論文
  2. 渡辺, 正勝 / WATANABE, Masakatsu

Somatic cell mutation and photoproduct formation in Drosophila induced by monochromatic UV light in sunlight

https://ir.soken.ac.jp/records/3868
https://ir.soken.ac.jp/records/3868
69114edf-7a1d-4041-8b2d-70ca29badcd9
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-08-09
タイトル
タイトル Somatic cell mutation and photoproduct formation in Drosophila induced by monochromatic UV light in sunlight
タイトル
タイトル Somatic cell mutation and photoproduct formation in Drosophila induced by monochromatic UV light in sunlight
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKINAMI, Shogo

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TAKINAMI, Shogo

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MOCHIZUKI, Misato

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MOCHIZUKI, Misato

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HAYATSU, Hikoya

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HAYATSU, Hikoya

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NIKAIDO, Osamu

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NIKAIDO, Osamu

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KUBOTA, Mamoru

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KUBOTA, Mamoru

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WATANABE, Masakatsu

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WATANABE, Masakatsu

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HIEDA, Miwako

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HIEDA, Miwako

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HIEDA, Kotaro

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HIEDA, Kotaro

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NEGISHI, Tomoe

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NEGISHI, Tomoe

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著者別名 渡辺, 正勝

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渡辺, 正勝

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抄録
内容記述タイプ Abstract
内容記述 We recently reported that natural sunlight can induce somatic mutation and chromosomal recombination in Drosophila, as detected by the wing spot test. Simultaneously, cyclobutane thymine dimers (CTDs) and (6-4)photoproducts [(6-4)PPs] are formed in the DNA. In the present work, we have performed monochromatic UV irradiation for evaluating the action spectrum of sunlight in genotoxicity. Third instar larvae in petri dishes were irradiated by monochromatic UV light at a wavelength between 310 and 360 nm. The mutant spots induced by the irradiation of 310, 320, 330, and 340 nm light were (4.4 ± 1.0) x 10 -1, (1.1 ± 0.2) x 10 -2, (2.5 ± 0.7) x 10 -3, and (2.0 ± 0.7) x 10 -3 spots/wing/kJ/m 2, respectively. The mutagenicity at 360 nm irradiation was not significant. The amounts of photoproducts in irradiated larval DNA were measured by an enzyme-linked immunosorbent assay (ELISA) using the monoclonal antibodies against CTDs and (6-4)PPs. CTDs were found in the DNA from all of these irradiated larvae, and their amounts increased with the UV dose: the longer the wavelength, the lower the CTD formation and the mutagenesis. These data suggest that, in the sunlight, the component around 310-340 nm causes the somatic cell mutation by forming thymine dimers as main lesions.
書誌情報 Environmental Toxicology
en : Environmental Toxicology

巻 15, 号 5, p. 496-499, 発行日 2000
出版者
出版者 Wiley-Blackwell
ISSN
収録物識別子タイプ ISSN
収録物識別子 15204081
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/1522-7278(2000)15:5<496::AID-TOX18>3.0.CO;2-M
関連名称 10.1002/1522-7278(2000)15:5<496::AID-TOX18>3.0.CO;2-M
権利
権利情報 © 2000 by John Wiley and Sons, Inc
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