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  1. 010 学術雑誌論文
  2. 渡辺, 正勝 / WATANABE, Masakatsu

UVA1 genotoxicity is mediated not by oxidative damage but by cyclobutane pyrimidine dimers in normal mouse skin

https://ir.soken.ac.jp/records/3876
https://ir.soken.ac.jp/records/3876
1bd0250c-0dd9-481d-830d-979b3088563b
名前 / ファイル ライセンス アクション
jid200861a.pdf jid200861a (216.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-08-12
タイトル
タイトル UVA1 genotoxicity is mediated not by oxidative damage but by cyclobutane pyrimidine dimers in normal mouse skin
タイトル
タイトル UVA1 genotoxicity is mediated not by oxidative damage but by cyclobutane pyrimidine dimers in normal mouse skin
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 IKEHATA, Hironobu

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IKEHATA, Hironobu

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KAWAI, Kazuaki

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KAWAI, Kazuaki

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KOMURA, Jun-ichiro

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KOMURA, Jun-ichiro

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SAKATSUME, Ko

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SAKATSUME, Ko

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WANG, Liangcheng

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WANG, Liangcheng

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IMAI, Masaru

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IMAI, Masaru

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HIGASHI, Shoichi

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HIGASHI, Shoichi

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NIKAIDO, Osamu

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NIKAIDO, Osamu

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YAMAMOTO, Kazuo

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YAMAMOTO, Kazuo

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HIEDA, Kotaro

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HIEDA, Kotaro

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WATANABE, Masakatsu

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WATANABE, Masakatsu

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KASAI, Hiroshi

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KASAI, Hiroshi

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ONO, Tetsuya

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ONO, Tetsuya

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著者別名 渡辺, 正勝

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渡辺, 正勝

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抄録
内容記述タイプ Abstract
内容記述 UVA1 induces the formation of 8-hydroxy-2′-deoxyguanosines (8-OH-dGs) and cyclobutane pyrimidine dimers (CPDs) in the cellular genome. However, the relative contribution of each type of damage to the in vivo genotoxicity of UVA1 has not been clarified. We irradiated living mouse skin with 364-nm UVA1 laser light and analyzed the DNA damage formation and mutation induction in the epidermis and dermis. Although dose-dependent increases were observed for both 8-OH-dG and CPD, the mutation induction in the skin was found to result specifically from the CPD formation, based on the induced mutation spectra in the skin genome: the dominance of C → T transition at a dipyrimidine site. Moreover, these UV-specific mutations occurred preferentially at the 5′-TCG-3′ sequence, suggesting that CpG methylation and photosensitization-mediated triplet energy transfer to thymine contribute to the CPD-mediated UVA1 genotoxicity. Thus, it is the CPD formation, not the oxidative stress, that effectively brings about the genotoxicity in normal skin after UVA1 exposure. We also found differences in the responses to the UVA1 genotoxicity between the epidermis and the dermis: the mutation induction after UVA1 irradiation was suppressed in the dermis at all levels of irradiance examined, whereas it leveled off from a certain high irradiance in the epidermis.
書誌情報 Journal of Investigative Dermatology
en : Journal of Investigative Dermatology

巻 128, 号 9, p. 2289-2296, 発行日 2008-09
出版者
出版者 Nature Publishing Group
ISSN
収録物識別子タイプ ISSN
収録物識別子 0022202X
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 18356809
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/jid.2008.61
関連名称 10.1038/jid.2008.61
権利
権利情報 © 2008 The Society for Investigative Dermatology
関連サイト
識別子タイプ URI
関連識別子 http://www.nature.com/authors/policies/confidentiality.html
関連名称 Copyright
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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