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  1. 010 学術雑誌論文
  2. 渡辺, 正勝 / WATANABE, Masakatsu

Time course and spacial distribution of UV effects on human skin in organ culture

https://ir.soken.ac.jp/records/3879
https://ir.soken.ac.jp/records/3879
db6ffaeb-634f-4cb8-9e96-f85527869e67
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-08-13
タイトル
タイトル Time course and spacial distribution of UV effects on human skin in organ culture
タイトル
タイトル Time course and spacial distribution of UV effects on human skin in organ culture
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 MORI, Eiichiro

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MORI, Eiichiro

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TAKAHASHI, Akihisa

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TAKAHASHI, Akihisa

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KITAGAWA, Kou

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KITAGAWA, Kou

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KAKEI, Saki

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KAKEI, Saki

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TSUJINAKA, Daiki

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TSUJINAKA, Daiki

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UNNO, Megumi

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UNNO, Megumi

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NISHIKAWA, Shoko

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NISHIKAWA, Shoko

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OHNISHI, Ken

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OHNISHI, Ken

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HATOKO, Mitsuo

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HATOKO, Mitsuo

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MURATA, Norio

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MURATA, Norio

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WATANABE, Masakatsu

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WATANABE, Masakatsu

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FURUSAWA, Yoshiya

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FURUSAWA, Yoshiya

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OHNISHI, Takeo

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OHNISHI, Takeo

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著者別名 渡辺, 正勝

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渡辺, 正勝

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抄録
内容記述タイプ Abstract
内容記述 Apoptosis plays an important role in eliminating cells from populations when cells have been exposed to UV irradiation and damaged. Studies of cells in culture have provided some details of the mechanisms involved when stress response genes act after exposure to UV irradiation and other environmental stresses. However, little is known about the responses of intact sections of human skin growing in organ culture to UV irradiation. In the work reported here, it was found that the response of organ-cultured human skin after exposure to UV irradiation is different than the response of cultured cells. At wavelengths below 300 nm, the action spectrum obtained from organ-cultured skin samples showed a lower sensitivity than that observed at 300 nm, indicating that the overlying stratum corneum and upper epidermal cell layers had probably caused a selective absorption of incident UV radiation at some wavelengths. At 3 hours after UV irradiation, p53 was phosphorylated at Ser 15 and Ser 46, and accumulated in the cell nuclei, notably after exposure to 280-320 nm wavelengths. Accumulations of Bax, active Caspase-3 and cleaved PARP were detected in apoptotic cells at 24 hours post-exposure, along with a reduction of Bcl-2 levels, notably after exposure to 300-365 nm light. This difference in apoptotic responses may result from the characteristics of the different irradiation wavelengths used, and from details in the skin's structure. The data obtained in this study using an organ-culture system utilized direct measurements of the biological effects of different wavelengths of UV lights.
書誌情報 Journal of Radiation Research
en : Journal of Radiation Research

巻 49, 号 3, p. 269-277, 発行日 2008
出版者
出版者 Oxford University Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 04493060
PubMed番号
識別子タイプ PMID
関連識別子 18311036
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1269/jrr.07106
関連名称 10.1269/jrr.07106
権利
権利情報 © 2008 Japan Radiation Research Society
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