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Somatic-cell mutation induced by UVA and monochromatic UV radiation in repair-proficient and -deficient Drosophila melanogaster
https://ir.soken.ac.jp/records/3895
https://ir.soken.ac.jp/records/3895516c9844-59f2-4619-8f61-950ff0466003
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-08-14 | |||||
| タイトル | ||||||
| タイトル | Somatic-cell mutation induced by UVA and monochromatic UV radiation in repair-proficient and -deficient Drosophila melanogaster | |||||
| タイトル | ||||||
| タイトル | Somatic-cell mutation induced by UVA and monochromatic UV radiation in repair-proficient and -deficient Drosophila melanogaster | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
NEGISHI, Tomoe
× NEGISHI, Tomoe× NAGAOKA, Chisato× HAYATSU, Hikoya× SUZUKI, Keiji× HARA, Takahiro× KUBOTA, Mamoru× WATANABE, Masakatsu× HIEDA, Kotaro |
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| 著者別名 |
渡辺, 正勝
× 渡辺, 正勝 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Near-ultraviolet light (UVA: 320-400 nm) constitutes a major part of sunlight UV. It is important to know the effect of UVA on the biological activities of organisms on the earth. We have previously reported that black light induces somatic-cell mutation in Drosophila larvae. To investigate which wavelength of the UVA is responsible for the mutation we have now carried out a series of monochromatic irradiations (310, 320, 330, 340, 360, 380 and 400 nm) on Drosophila larvae, using the large spectrograph of the National Institute for Basic Biology (Okazaki National Research Institutes, Okazaki, Japan). Mutagenic activity was examined by the Drosophila wing-spot test in which we observe mutant wing hair colonies (spots) on the wings of adult flies obtained from the treated larvae. The induction of mutation was highest by irradiation at 310 nm and decreased as the wavelength became longer. Neither the 380 nor the 400 nm light was mutagenic. Excision repair is known to protect cells from UV damage. In the excision-repair-deficient Drosophila, the mutagenic response induced by 310 nm irradiation was 24-fold higher than that of the wild-type (7.2 ± 1.5 spots/wing/kJ vs 0.3 ± 0.08 spots/wing/kJ), and at 320 nm the difference of the response was 14-fold (0.21 vs 0.015 ± 0.005). In the case of irradiation at 330 and 340 nm the difference of the response was only two-fold (at 330 nm, 6.9 ± 2.9 × 10 -3 vs 3.1 ± 1.1 × 10 -3 spots/wing/kJ; at 340 nm, 3.5 ± 0.9 × 10 -3 vs 2.0 ± 0.7 × 10 -3). These results suggest that the lesion caused in the larvae by 320 nm irradiation may be similar to the damage induced by 310 nm and that the lights of 330 and 340 nm may induce damage different from the lesions induced by shorter-wavelength lights. | |||||
| 書誌情報 |
Photochemistry and Photobiology en : Photochemistry and Photobiology 巻 73, 号 5, p. 493-498, 発行日 2001-05 |
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| 出版者 | ||||||
| 出版者 | Wiley-Blackwell | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00318655 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1562/0031-8655(2001)0730493SCMIBU2.0.CO2 | |||||
| 関連名称 | 10.1562/0031-8655(2001)0730493SCMIBU2.0.CO2 | |||||
| 権利 | ||||||
| 権利情報 | © 2001 The Authors. Photochemistry and Photobiology © 2001 The American Society of Photobiology | |||||
