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  1. 010 学術雑誌論文
  2. 田辺, 秀之 / TANABE, Hideyuki

The actin family member Arp6 and the histone variant H2A.Z are required for spatial positioning of chromatin in chicken cell nuclei

https://ir.soken.ac.jp/records/3954
https://ir.soken.ac.jp/records/3954
4ef15f4c-d20a-40ca-8402-2b56fbc62c60
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-09-18
タイトル
タイトル The actin family member Arp6 and the histone variant H2A.Z are required for spatial positioning of chromatin in chicken cell nuclei
タイトル
タイトル The actin family member Arp6 and the histone variant H2A.Z are required for spatial positioning of chromatin in chicken cell nuclei
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 MARUYAMA, Eri Ohfuchi

× MARUYAMA, Eri Ohfuchi

MARUYAMA, Eri Ohfuchi

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HORI, Tetsuya

× HORI, Tetsuya

HORI, Tetsuya

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TANABE, Hideyuki

× TANABE, Hideyuki

TANABE, Hideyuki

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et, al.

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et, al.

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著者別名 田辺 , 秀之

× 田辺 , 秀之

田辺 , 秀之

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抄録
内容記述タイプ Abstract
内容記述 The spatial organization of chromatin in the nucleus contributes to genome function and is altered during the differentiation of normal and tumorigenic cells. Although nuclear actin-related proteins (Arps) have roles in the local alteration of chromatin structure, it is unclear whether they are involved in the spatial positioning of chromatin. In the interphase nucleus of vertebrate cells, gene-dense and gene-poor chromosome territories (CTs) are located in the center and periphery, respectively. We analyzed chicken DT40 cells in which Arp6 had been knocked out conditionally, and showed that the radial distribution of CTs was impaired in these knockout cells. Arp6 is an essential component of the SRCAP chromatin remodeling complex, which deposits the histone variant H2A.Z into chromatin. The redistribution of CTs was also observed in H2A.Z-deficient cells for gene-rich microchromosomes, but to lesser extent for gene-poor macrochromosomes. These results indicate that Arp6 and H2A.Z contribute to the radial distribution of CTs through different mechanisms. Microarray analysis suggested that the localization of chromatin to the nuclear periphery per se is insufficient for the repression of most genes.
書誌情報 Journal of Cell Science
en : Journal of Cell Science

巻 125, 号 16, p. 3739-3744, 発行日 2012-08-15
出版者
出版者 The Company of Biologists Ltd
ISSN
収録物識別子タイプ ISSN
収録物識別子 0021-9533
DOI
識別子タイプ DOI
関連識別子 http://doi.org/10.1242/jcs.103903
関連名称 10.1242/jcs.103903
権利
権利情報 © The Company of Biologists Ltd 2013
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