| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-09-18 |
| タイトル |
|
|
タイトル |
Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor |
| タイトル |
|
|
タイトル |
Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
OIKAWA, Kosuke
YOSHIDA, Keiichi
TAKANASHI, Masakatsu
TANABE, Hideyuki
et, al.
|
| 著者別名 |
田辺, 秀之
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Each chromosome occupies its own-specific space called a ‘territory’ within the interphase nucleus, and the arrangement of chromosome territories (CTs) is important in epigenetic mechanisms. The molecular mechanism to determine the positioning of CTs, however, remains unknown. On the other hand, dioxin is known to be the typical environmental pollutant that affects a wide variety of biological events in many species. Here, we show that dioxin enlarges the minimum distance between chromosome 12 and chromosome 16 territories in human preadipocyte cells, and the alteration of chromosome positioning is canceled by an aryl hydrocarbon receptor (AhR) antagonist α-naphthoflavone. Thus, AhR may be a key molecule to regulate chromosome positioning. Our results suggest a novel effect of dioxin toxicity, and demonstrate a clue to reveal the novel molecular mechanism for the arrangement of CTs. |
| 書誌情報 |
Biochemical and Biophysical Research Communications
en : Biochemical and Biophysical Research Communications
巻 374,
号 2,
p. 361-364,
発行日 2008-09-19
|
| 出版者 |
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|
出版者 |
Elsevier |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0006-291X |
| DOI |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.bbrc.2008.07.044 |
|
|
関連名称 |
10.1016/jbbrc.2008.07.044 |
| 権利 |
|
|
権利情報 |
© 2008 Elsevier Inc |
