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  1. 010 学術雑誌論文
  2. 田辺, 秀之 / TANABE, Hideyuki

Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor

https://ir.soken.ac.jp/records/3963
https://ir.soken.ac.jp/records/3963
6c78a4c6-72ad-4088-9384-f11f923400f0
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-09-18
タイトル
タイトル Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor
タイトル
タイトル Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 OIKAWA, Kosuke

× OIKAWA, Kosuke

OIKAWA, Kosuke

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YOSHIDA, Keiichi

× YOSHIDA, Keiichi

YOSHIDA, Keiichi

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TAKANASHI, Masakatsu

× TAKANASHI, Masakatsu

TAKANASHI, Masakatsu

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TANABE, Hideyuki

× TANABE, Hideyuki

TANABE, Hideyuki

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et, al.

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et, al.

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著者別名 田辺, 秀之

× 田辺, 秀之

田辺, 秀之

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抄録
内容記述タイプ Abstract
内容記述 Each chromosome occupies its own-specific space called a ‘territory’ within the interphase nucleus, and the arrangement of chromosome territories (CTs) is important in epigenetic mechanisms. The molecular mechanism to determine the positioning of CTs, however, remains unknown. On the other hand, dioxin is known to be the typical environmental pollutant that affects a wide variety of biological events in many species. Here, we show that dioxin enlarges the minimum distance between chromosome 12 and chromosome 16 territories in human preadipocyte cells, and the alteration of chromosome positioning is canceled by an aryl hydrocarbon receptor (AhR) antagonist α-naphthoflavone. Thus, AhR may be a key molecule to regulate chromosome positioning. Our results suggest a novel effect of dioxin toxicity, and demonstrate a clue to reveal the novel molecular mechanism for the arrangement of CTs.
書誌情報 Biochemical and Biophysical Research Communications
en : Biochemical and Biophysical Research Communications

巻 374, 号 2, p. 361-364, 発行日 2008-09-19
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 0006-291X
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.bbrc.2008.07.044
関連名称 10.1016/jbbrc.2008.07.044
権利
権利情報 © 2008 Elsevier Inc
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