| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-09-18 |
| タイトル |
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タイトル |
NELF interacts with CBC and participates in 3 ' end processing of replication-dependent histone rnRNAs |
| タイトル |
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タイトル |
NELF interacts with CBC and participates in 3 ' end processing of replication-dependent histone rnRNAs |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
NARITA, Takashi
YUNG, Tetsu M. C
YAMAMOTO, Junichi
TSUBOI, Yasunori
TANABE, Hideyuki
TANAKA, Kiyoji
YAMAGUCHI, Yuki
HANDA, Hiroshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Negative elongation factor (NELF) is a four subunit transcription elongation factor that has been implicated in numerous diseases ranging from neurological disorders to cancer. Here we show that NELF interacts with the nuclear cap binding complex (CBC), a multifunctional factor that plays important roles in several mRNA processing steps, and the two factors together participate in the 3′ end processing of replication-dependent histone mRNAs, most likely through association with the histone stem-loop binding protein (SLBP). Strikingly, absence of NELF and CBC causes aberrant production of polyadenylated histone mRNAs. Moreover, NELF is physically associated with histone gene loci and forms distinct intranuclear foci that we call NELF bodies, which often overlap with Cajal bodies and cleavage bodies. Our results point to a surprising role of NELF in the 3′ end processing of histone mRNAs and also suggest that NELF is a new factor that coordinates different mRNA processing steps during transcription. |
| 書誌情報 |
Molecular Cell
en : Molecular Cell
巻 26,
号 3,
p. 349-365,
発行日 2007-05-11
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| 出版者 |
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出版者 |
Elsevier |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1097-2765 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.molcel.2007.04.011 |
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関連名称 |
10.1016/j.molcel.2007.04.011 |
| 権利 |
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権利情報 |
© 2007 Elsevier Inc |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://www.cell.com/authors |
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関連名称 |
Copyright |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
1-s2.0-S1097276507002274-main (2.2 MB)
