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  1. 010 学術雑誌論文
  2. 田辺, 秀之 / TANABE, Hideyuki

NELF interacts with CBC and participates in 3 ' end processing of replication-dependent histone rnRNAs

https://ir.soken.ac.jp/records/3965
https://ir.soken.ac.jp/records/3965
bbed93fc-bdf7-47f3-ba7c-251d1bc75a9d
名前 / ファイル ライセンス アクション
1-s2.0-S1097276507002274-main.pdf 1-s2.0-S1097276507002274-main (2.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-09-18
タイトル
タイトル NELF interacts with CBC and participates in 3 ' end processing of replication-dependent histone rnRNAs
タイトル
タイトル NELF interacts with CBC and participates in 3 ' end processing of replication-dependent histone rnRNAs
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 NARITA, Takashi

× NARITA, Takashi

NARITA, Takashi

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YUNG, Tetsu M. C

× YUNG, Tetsu M. C

YUNG, Tetsu M. C

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YAMAMOTO, Junichi

× YAMAMOTO, Junichi

YAMAMOTO, Junichi

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TSUBOI, Yasunori

× TSUBOI, Yasunori

TSUBOI, Yasunori

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TANABE, Hideyuki

× TANABE, Hideyuki

TANABE, Hideyuki

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TANAKA, Kiyoji

× TANAKA, Kiyoji

TANAKA, Kiyoji

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YAMAGUCHI, Yuki

× YAMAGUCHI, Yuki

YAMAGUCHI, Yuki

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HANDA, Hiroshi

× HANDA, Hiroshi

HANDA, Hiroshi

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抄録
内容記述タイプ Abstract
内容記述 Negative elongation factor (NELF) is a four subunit transcription elongation factor that has been implicated in numerous diseases ranging from neurological disorders to cancer. Here we show that NELF interacts with the nuclear cap binding complex (CBC), a multifunctional factor that plays important roles in several mRNA processing steps, and the two factors together participate in the 3′ end processing of replication-dependent histone mRNAs, most likely through association with the histone stem-loop binding protein (SLBP). Strikingly, absence of NELF and CBC causes aberrant production of polyadenylated histone mRNAs. Moreover, NELF is physically associated with histone gene loci and forms distinct intranuclear foci that we call NELF bodies, which often overlap with Cajal bodies and cleavage bodies. Our results point to a surprising role of NELF in the 3′ end processing of histone mRNAs and also suggest that NELF is a new factor that coordinates different mRNA processing steps during transcription.
書誌情報 Molecular Cell
en : Molecular Cell

巻 26, 号 3, p. 349-365, 発行日 2007-05-11
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 1097-2765
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.molcel.2007.04.011
関連名称 10.1016/j.molcel.2007.04.011
権利
権利情報 © 2007 Elsevier Inc
関連サイト
識別子タイプ URI
関連識別子 http://www.cell.com/authors
関連名称 Copyright
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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