ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 010 学術雑誌論文
  2. 田辺, 秀之 / TANABE, Hideyuki

GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen

https://ir.soken.ac.jp/records/3966
https://ir.soken.ac.jp/records/3966
d71f6ac8-9f6c-4260-b9f8-1415136049f1
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-09-19
タイトル
タイトル GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen
タイトル
タイトル GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 MORIYAMA, Akemi

× MORIYAMA, Akemi

MORIYAMA, Akemi

Search repository
KII, Isad

× KII, Isad

KII, Isad

Search repository
SUNABORI, Takehiko

× SUNABORI, Takehiko

SUNABORI, Takehiko

Search repository
KURIHARA, Suguru

× KURIHARA, Suguru

KURIHARA, Suguru

Search repository
TAKAYAMA, Issei

× TAKAYAMA, Issei

TAKAYAMA, Issei

Search repository
SHIMAZAKI, Masashi

× SHIMAZAKI, Masashi

SHIMAZAKI, Masashi

Search repository
TANABE, Hideyuki

× TANABE, Hideyuki

TANABE, Hideyuki

Search repository
et, al.

× et, al.

et, al.

Search repository
著者別名 田辺, 秀之

× 田辺, 秀之

田辺, 秀之

Search repository
抄録
内容記述タイプ Abstract
内容記述 In the past decades, the function of the Wnt canonical pathway during embryogenesis has been intensively investigated; however, little survey of neonatal and adult tissues has been made, and the role of this pathway remains largely unknown. To investigate its role in mature tissues, we generated two new reporter transgenic mouse lines, ins-TOPEGFP and ins-TOPGAL, that drive EGFP and β-galactosidase expression under TCF/β-catenin, respectively. To obtain the accurate expression pattern, we flanked these transgenes with the HS4 insulator to reduce chromosomal positional effects. Analysis of embryos showed that the reporter genes were activated in regions where canonical Wnt activity has been implicated. Furthermore, their expression patterns were consistent in both lines, indicating the accuracy of the reporter signal. In the neonatal brain, the reporter signal was detected in the mesencephalon and hippocampus. In the adult mice, the reporter signal was found in the mature pericenteral hepatocytes in the normal liver. Furthermore, during inflammation the number of T cells expressing the reporter gene increased in the adult spleen. Thus, in this research, we identified two organs, i.e., the liver and spleen, as novel organs in which the Wnt canonical signal is in motion in the adult. These transgenic lines will provide us broader opportunities to investigate the function of the Wnt canonical pathway in vivo.
書誌情報 Genesis
en : Genesis

巻 45, 号 2, p. 90-100, 発行日 2007-02
出版者
出版者 Wiley-Blackwell
ISSN
収録物識別子タイプ ISSN
収録物識別子 1526-954X
権利
権利情報 © 2007 Wiley-Liss, Inc
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-20 14:16:06.003943
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3