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Alteration of chromosome positioning during adipocyte differentiation
https://ir.soken.ac.jp/records/3974
https://ir.soken.ac.jp/records/39748cf77ec1-4d78-415e-817a-1dd151927bbe
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
5897.full (353.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-09-19 | |||||
| タイトル | ||||||
| タイトル | Alteration of chromosome positioning during adipocyte differentiation | |||||
| タイトル | ||||||
| タイトル | Alteration of chromosome positioning during adipocyte differentiation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
KURODA, Masahiko
× KURODA, Masahiko× TANABE, Hideyuki× et, al. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Chromosomes are highly restricted to specific chromosome territories within the interphase nucleus. The arrangement of chromosome territories is non-random, exhibiting a defined radial distribution as well as a preferential association with specific nuclear compartments, which indicates a functional role for chromosome-territory organization in the regulation of gene expression. In this report, we focus on changes in adipocyte differentiation that are related to a specific chromosomal translocation associated with liposarcoma tumorigenesis, t(12;16). We have examined the relative and radial positioning of the chromosome territories of human chromosomes 12 and 16 during adipocyte differentiation, and detected a close association between the territories of chromosomes 12 and 16 in differentiated adipocytes, an association not observed in preadipocytes. Although further studies are required to elucidate the underlying reasons for the adipocyte-specific translocation of chromosomes 12 and 16, our observations indicate that alteration of relative chromosome positioning might play a key role in the tumorigenesis of human liposarcomas. In addition, these results demonstrate the potential impact of higher order chromatin organization on the epigenetic mechanisms that control gene expression and gene silencing during cell differentiation. | |||||
| 書誌情報 |
Journal of Cell Science en : Journal of Cell Science 巻 117, 号 24, p. 5897-5903, 発行日 2004-11-15 |
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| 出版者 | ||||||
| 出版者 | The Company of Biologists Ltd | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0021-9533 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://doi.org/10.1242/jcs.01508 | |||||
| 関連名称 | 10.1242/jcs.01508 | |||||
| 権利 | ||||||
| 権利情報 | © The Company of Biologists Limited 2004 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.biologists.com/copyright_permissions.html | |||||
| 関連名称 | Copyright | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
