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Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients
https://ir.soken.ac.jp/records/3977
https://ir.soken.ac.jp/records/39778d62edb2-9ca6-487e-9837-37f1ce832a68
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-09-20 | |||||
| タイトル | ||||||
| タイトル | Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients | |||||
| タイトル | ||||||
| タイトル | Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
HONMA, Masamitsu
× HONMA, Masamitsu× TADOKORO, Satoshi× SAKAMOTO, Hiroko |
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| 著者別名 |
田辺, 秀之
× 田辺, 秀之 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Werner’s syndrome (WS) and Bloom’s syndrome (BS) are rare autosomal genetic diseases that predispose to cancer and are associated with genomic instability. To characterize the genomic instability of WS and BS, we analyzed and compared the cytogenetics of B-lymphoblastoid cell lines (LCLs) from WS and BS patients and healthy donors. Although, similar spontaneous frequencies of micronuclei (MN) and sister chromatid exchanges (SCE) were observed in LCLs from WS patients and healthy donors, they were much higher in BS-LCLs. We also examined the cells’ cytotoxic and cytogenetic formation (MN) response to camptothecin (CAM), etoposide (ETO), 4-nitroquinoline 1-oxide (4NQO), and mitomycin C (MMC). Compared to healthy donor LCLs, BS-LCLs but not WS-LCLs tended to be resistant to cytotoxicity and sensitive to MN induction by 4NQO and MMC. Spectrum karyotyping analysis revealed that most WS- and BS-LCLs generated “variegated translocation mosaicism” at high frequencies during cell culture. These findings support the idea that the basis of genomic instability in WS is different from that in BS. | |||||
| 書誌情報 |
Mutation Research - Genetic Toxicology and Environmental Mutagenesis en : Mutation Research - Genetic Toxicology and Environmental Mutagenesis 巻 520, 号 1-2, p. 15-24, 発行日 2002-09-26 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1383-5718 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/S1383-5718(02)00144-4 | |||||
| 関連名称 | 10.1016/S1383-5718(02)00144-4 | |||||
| 権利 | ||||||
| 権利情報 | © 2002 Elsevier Science B.V. | |||||
