| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-09-20 |
| タイトル |
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タイトル |
Non-random radial arrangements of interphase chromosome territories: evolutionary considerations and functional implications |
| タイトル |
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タイトル |
Non-random radial arrangements of interphase chromosome territories: evolutionary considerations and functional implications |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
TANABE, Hideyuki
A Habermannb, FELIX
IRINA, Solovei
CREMER, Marion
CREMER, Thomas
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| 著者別名 |
田辺, 秀之
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
In the nucleus of animal and plant cells individual chromosomes maintain a compartmentalized structure. Chromosome territories (CTs), as these structures were named by Theodor Boveri, are essential components of the higher-order chromatin architecture. Recent studies in mammals and non-mammalian vertebrates indicate that the radial position of a given CT (or segments thereof) is correlated with its size, its gene-density and its replication timing. As a representative case, chicken cell nuclei show highly consistent radial chromatin arrangements: gene-rich, early replicating microchromosomes are clustered within the nuclear interior, while gene-poor, later replicating macrochromosomes are preferentially located at the nuclear periphery. In humans, chromosomes 18 and 19 (HSA18 and 19) territories that are of similar size show a distinctly different position in the cell nuclei of lymphocytes and lymphoblastoid cells: the gene-rich and early replicating HSA19 CTs are typically found close to the nuclear center, while the gene-poor and later replicating HSA18 CTs are preferentially located at the nuclear periphery. Recent comparative maps between human and chicken chromosomes revealed that the chicken macrochromosomes 2 and Z contain the genes homologous to HSA18, while the genes on HSA19 are located onto the chicken microchromosomes. These data lend tentative support to the hypothesis that differences in the radial nuclear positions of gene-rich, early replicating and gene-poor, later replicating chromatin have been evolutionarily conserved during a period of more than 300 million years irrespective of the evolution of highly divergent karyotypes between humans and chicken. |
| 書誌情報 |
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
en : Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
巻 504,
号 1-2,
p. 37-45,
発行日 2002-07-25
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| 出版者 |
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出版者 |
Elsevier |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0027-5107 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/S0027-5107(02)00077-5 |
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関連名称 |
10.1016/S0027-5107(02)00077-5 |
| 権利 |
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権利情報 |
© 2002 Elsevier Science B.V. |
