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  1. 010 学術雑誌論文
  2. 田辺, 秀之 / TANABE, Hideyuki

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells

https://ir.soken.ac.jp/records/3983
https://ir.soken.ac.jp/records/3983
b30e1fd4-6513-4f89-8b53-155b6a18da47
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-09-25
タイトル
タイトル Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells
タイトル
タイトル Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 IMAMURA, Osamu

× IMAMURA, Osamu

IMAMURA, Osamu

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FUJITA, Kumiko

× FUJITA, Kumiko

FUJITA, Kumiko

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SHIMAMOTO, Akira

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SHIMAMOTO, Akira

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TANABE, Hideyuki

× TANABE, Hideyuki

TANABE, Hideyuki

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TAKEDA, Shunichi

× TAKEDA, Shunichi

TAKEDA, Shunichi

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FURUICHI, Yasuhiro

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FURUICHI, Yasuhiro

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MATSUMOTO, Takehisa

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MATSUMOTO, Takehisa

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著者別名 田辺, 秀之

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田辺, 秀之

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抄録
内容記述タイプ Abstract
内容記述 Bloom syndrome (BS) is a recessive human genetic disorder characterized by short stature, immunodeficiency and an elevated risk of malignancy. The gene mutated in BS, BLM, encodes a RecQ-type DNA helicase. BS cells have mutator phenotypes such as hyper-recombination, chromosome instability and an increased frequency of sister chromatid exchange (SCE). To define the primary role of BLM, we generated BLM(-/-) mutants of the chicken B-cell line DT40. In addition to characteristics of BLM(-/-) cells reported previously by the other group, they are hypersensitive to genotoxic agents such as etoposide, bleomycin and 4-nitroquinoline-1-oxide and irradiation with the short wave length of UV (UVC) light, whereas they exhibit normal sensitivity to X-ray irradiation and hydroxyurea. UVC irradiation to BLM(-/-) cells during G(1) to early S phase caused chromosomal instability such as chromatid breaks and chromosomal quadriradials, leading to eventual cell death. These results suggest that BLM is involved in surveillance of base abnormalities in genomic DNA that may be encountered by replication forks in early S phase. Such surveillance would maintain genomic stability in vertebrate cells, resulting in the prevention of cellular tumorigenesis.
書誌情報 Oncogene
en : Oncogene

巻 20, 号 10, p. 1143-1151, 発行日 2001-03-08
出版者
出版者 Nature Publishing Group
ISSN
収録物識別子タイプ ISSN
収録物識別子 0950-9232
DOI
識別子タイプ DOI
関連識別子 http://doi.org/10.1038/sj.onc.1204195
関連名称 10.1038/sj.onc.1204195
権利
権利情報 © 2001 Nature Publishing Group
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