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  1. 010 学術雑誌論文
  2. 田辺, 秀之 / TANABE, Hideyuki

Extensive genetic heterogeneity in the neuroblastoma cell line NB(TU)1

https://ir.soken.ac.jp/records/3986
https://ir.soken.ac.jp/records/3986
16edac79-0a51-42bb-8c2e-a369fddd0b3a
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-09-25
タイトル
タイトル Extensive genetic heterogeneity in the neuroblastoma cell line NB(TU)1
タイトル
言語 en
タイトル Extensive genetic heterogeneity in the neuroblastoma cell line NB(TU)1
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 INOUE, Akira

× INOUE, Akira

WEKO 2139

INOUE, Akira

Search repository
YOKOMORI, Kinji

× YOKOMORI, Kinji

WEKO 2140

YOKOMORI, Kinji

Search repository
TANABE, Hideyuki

× TANABE, Hideyuki

WEKO 368

TANABE, Hideyuki

Search repository
MIZUSAWA, Hiroshi

× MIZUSAWA, Hiroshi

WEKO 1312

MIZUSAWA, Hiroshi

Search repository
SOFUNI, Toshio

× SOFUNI, Toshio

WEKO 2132

SOFUNI, Toshio

Search repository
HAYASHI, Yasuhide

× HAYASHI, Yasuhide

WEKO 2141

HAYASHI, Yasuhide

Search repository
TSUCHIDA, Yoshiaki

× TSUCHIDA, Yoshiaki

WEKO 2142

TSUCHIDA, Yoshiaki

Search repository
SHIMATAKE, Hiroyuki

× SHIMATAKE, Hiroyuki

WEKO 2143

SHIMATAKE, Hiroyuki

Search repository
著者別名 田辺, 秀之

× 田辺, 秀之

WEKO 367
NRID 1000050261178
e-Rad 50261178

田辺, 秀之

Search repository
抄録
内容記述タイプ Abstract
内容記述 A neuroblastoma cell line displaying genetically unique features was established from a stage III case of a 20-month-old girl. Southern blotting by the probe pTNB6, which contains exon 1 of the N-myc gene, showed that the primary tumor had in total 4 aberrant bands beside the normal amplified band. The established cell line NB(TU)1 had an aberrant N-myc band (9.0 kb) in addition to the normal band (2.9 kb). Cytogenetic analysis revealed that NB(TU)1 has a composite karyotype composed of at least 7 related karyotypes, which are pseudo-diploid and contain complex chromosomal abnormalities, including translocations, deletions and homogeneously staining regions (HSRs). Such extensive abnormalities were considered to be prominent among known neuroblastoma cell lines, and it was suggested that NB(TU)1 had acquired a certain type of genetic instability. Analysis of N-myc bands in 11 clones of NB(TU)1 showed that the intensity ratio of the normal-sized band (2.9 kb) and the aberrant one (9.0 kb) markedly varied among clones. Moreover, 3 clones showed an additional band with the size of 3.7 kb, which was detectable neither in the parent NB(TU)1 nor in the primary tumor. Thus, NB(TU)1 was shown to be composed of heterogeneous cell components. To further detect such ongoing chromosomal instability, we examined micronuclei formation. NB(TU)1 yielded a larger number of micronuclei than 5 other neuroblastoma cell lines. We conclude that NB(TU)1 has acquired genetic instability detectable by both Southern blotting and cytogenetic analysis.
書誌情報 International Journal of Cancer
en : International Journal of Cancer

巻 72, 号 6, p. 1070-1077, 発行日 1997-09-17
出版者
出版者 Wiley-Blackwell
ISSN
収録物識別子タイプ ISSN
収録物識別子 0020-7136
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/(SICI)1097-0215(19970917)72:6<1070::AID-IJC23>3.0.CO;2-7
関連名称 10.1002/(SICI)1097-0215(19970917)72:6<1070::AID-IJC23>3.0.CO;2-7
権利
権利情報 © 1997 Wiley-Liss, Inc
関連サイト
識別子タイプ URI
関連識別子 h
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