| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-10-09 |
| タイトル |
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タイトル |
The neutral theory and natural selection in the HLA region |
| タイトル |
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タイトル |
The neutral theory and natural selection in the HLA region |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
SATTA, Yoko
LI, Yi-Ju
TAKAHATA, Naoyuki
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Based on available DNA sequence data in the HLA region of 4 Mb, we review the degree of polymorphism at 39 loci of which most are involved in the immune system. The extent of nucleotide differences per silent site differs greatly from locus to locus. It is exceptionally high at classical MHC loci, intermediate at six MHC-related pseudogenes as well as at some loci in class I and II regions, and low in the class III region. Different exons of individual MHC loci show also different degrees of silent polymorphism; high in the exons encoding for the peptide binding region (PBR) and low in the exons encoding for trans-membranes and cytoplasmic tails. The degree of polymorphism within MHC allelic lineages is not much smaller than that between allelic lineages, contrary to the expectation where intra-allelic sequence exchanges are restricted. The observation that many allelic lineages at the HLA-DRB1 locus are combinations of distinct motifs in the beta pleated sheet and alpha helix of PBR indicates that sequence exchanges occur even within exon 2. Semi-quantitative analysis is presented about the rate of sequence exchanges between selected and linked neutral regions, although more sequence information is necessary to make definite conclusions. The extraordinary MHC polymorphism is viewed from the dual function of MHC molecules that controls the acquired immune system. |
| 書誌情報 |
Frontiers in Bioscience
en : Frontiers in Bioscience
巻 3,
号 d,
p. 459-467,
発行日 1998-04-27
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| 出版者 |
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出版者 |
Frontiers in Bioscience |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1093-9946 |
| 権利 |
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権利情報 |
© Frontiers in Bioscience |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://www.frontiersin.org/about/PublishingFees |
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関連名称 |
Copyright |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://www.bioscience.org/1998/v3/d/satta/d459-467.htm |
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関連名称 |
Frontiers in Bioscience |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
satta (336.9 kB)
