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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

The neutral theory and natural selection in the HLA region

https://ir.soken.ac.jp/records/3998
https://ir.soken.ac.jp/records/3998
cd03b506-dd22-4a96-856d-e4ef70681d70
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satta.pdf satta (336.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-10-09
タイトル
タイトル The neutral theory and natural selection in the HLA region
タイトル
タイトル The neutral theory and natural selection in the HLA region
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

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LI, Yi-Ju

× LI, Yi-Ju

LI, Yi-Ju

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 Based on available DNA sequence data in the HLA region of 4 Mb, we review the degree of polymorphism at 39 loci of which most are involved in the immune system. The extent of nucleotide differences per silent site differs greatly from locus to locus. It is exceptionally high at classical MHC loci, intermediate at six MHC-related pseudogenes as well as at some loci in class I and II regions, and low in the class III region. Different exons of individual MHC loci show also different degrees of silent polymorphism; high in the exons encoding for the peptide binding region (PBR) and low in the exons encoding for trans-membranes and cytoplasmic tails. The degree of polymorphism within MHC allelic lineages is not much smaller than that between allelic lineages, contrary to the expectation where intra-allelic sequence exchanges are restricted. The observation that many allelic lineages at the HLA-DRB1 locus are combinations of distinct motifs in the beta pleated sheet and alpha helix of PBR indicates that sequence exchanges occur even within exon 2. Semi-quantitative analysis is presented about the rate of sequence exchanges between selected and linked neutral regions, although more sequence information is necessary to make definite conclusions. The extraordinary MHC polymorphism is viewed from the dual function of MHC molecules that controls the acquired immune system.
書誌情報 Frontiers in Bioscience
en : Frontiers in Bioscience

巻 3, 号 d, p. 459-467, 発行日 1998-04-27
出版者
出版者 Frontiers in Bioscience
ISSN
収録物識別子タイプ ISSN
収録物識別子 1093-9946
権利
権利情報 © Frontiers in Bioscience
関連サイト
識別子タイプ URI
関連識別子 http://www.frontiersin.org/about/PublishingFees
関連名称 Copyright
関連サイト
識別子タイプ URI
関連識別子 http://www.bioscience.org/1998/v3/d/satta/d459-467.htm
関連名称 Frontiers in Bioscience
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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