| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-10-09 |
| タイトル |
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タイトル |
Origins of mouse inbred strains deduced from whole-genome scanning by polymorphic microsatellite loci |
| タイトル |
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タイトル |
Origins of mouse inbred strains deduced from whole-genome scanning by polymorphic microsatellite loci |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
SAKAI, Takahiro
KIKKAWA, Yoshiaki
MIURA, Ikuo
INOUE, Takeshi
MORIWAKI, Kazuo
SHIROISHI, Toshihiko
SATTA, Yoko
TAKAHATA, Naoyuki
YONEKAWA, Hiromichi
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Microsatellite loci are uniformly distributed at approximately 100-kbp intervals on all chromosomes except the chromosome Y, and genetic information about more than 9000 loci and high-throughput polymorphism analysis are now available. Taking advantage of these properties, we carried out whole-genome scanning using eight common inbred strains (CIS) of laboratory mice, including A/J, C57BL/6J, CBA/J, DBA/2J, SM/J, SWR/J, NC/Nga, and 129/SvJ, and eight wild-derived inbred strains (WIS), BGL2/Ms, CAST/Ei, JF1/Ms, MSM/Ms, NJL/Ms, PGN2/Ms, SK/CamEi, and SWN/Ms. We selected and located 1226 informative loci at 1.2-cM average intervals on all of the chromosomes of the 16 strains and compared the polymorphisms of the eight CIS with those from the eight WIS as subspecies representatives. More than 50% of the loci can be identified as WIS (therefore, subspecies-specific) alleles in the CIS genomes. We also discovered that the CIS chromosomes form a mosaic structure with an average ratio of domesticus to non-domesticus alleles of 3:1. Furthermore, the domesticus alleles were present much more frequently on the CIS chromosome X than on their autosomes, suggesting that successive backcrossing of non-domesticus stocks to domesticus stocks had been undergone at the beginning of CIS history. |
| 書誌情報 |
Mammalian Genome
en : Mammalian Genome
巻 16,
号 1,
p. 11-19,
発行日 2005-01
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| 出版者 |
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出版者 |
SpringerLink |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0938-8990 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1007/s00344-004-3013-9 |
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関連名称 |
10.1007/s00344-004-3013-9 |
| 権利 |
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権利情報 |
SpringerLink(The original publication is available at www.springerlink.com) |
