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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Intensity of natural selection at the major histocompatibility complex loci

https://ir.soken.ac.jp/records/4004
https://ir.soken.ac.jp/records/4004
b74243ea-5143-4be8-8f1f-254013fc9dc1
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-10-09
タイトル
タイトル Intensity of natural selection at the major histocompatibility complex loci
タイトル
言語 en
タイトル Intensity of natural selection at the major histocompatibility complex loci
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 SATTA, Yoko

× SATTA, Yoko

WEKO 357

SATTA, Yoko

Search repository
O'hUIGIN, Colm

× O'hUIGIN, Colm

WEKO 2167

O'hUIGIN, Colm

Search repository
TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

WEKO 778

TAKAHATA, Naoyuki

Search repository
KLEIN, Jan

× KLEIN, Jan

WEKO 1552

KLEIN, Jan

Search repository
著者別名 尚之, 高畑

× 尚之, 高畑

WEKO 1577
NRID 1000030124217
e-Rad 30124217

尚之, 高畑

Search repository
抄録
内容記述タイプ Abstract
内容記述 Long persistence of allelic lineages, prevalence of nonsynonymous over synonymous substitutions in the peptide-binding region (PBR), and deviation from neutrality of the expected gene identity parameter F all indicate indirectly that balancing selection is operating at functional major histocompatibility complex (MHC) loci. Direct demonstrations of the existence of balancing selection at MHC loci are, however, either lacking or not fully convincing. To define the conditions under which balancing selection could be demonstrated, we estimated its intensity from the mean number of nonsynonymous substitutions, KB, at the PBR and the mutation rate mu. We compared the five available methods for estimating KB by computer simulation and chose the most reliable ones for estimation of selection intensity. For the human MHC, the selection coefficients of the HLA-A, -B, -C, -DRB1, -DQB1, -DQA1, and -DPB1 loci are 0.015, 0.042, 0.0026, 0.019, 0.0085, 0.0028, and 0.0007, respectively. This low selection intensity places severe restrictions on the possibility of measuring selection directly in vertebrate populations.
書誌情報 Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America

巻 91, 号 15, p. 7184-7188, 発行日 1994-07-19
出版者
出版者 National Academy of Sciences
ISSN
収録物識別子タイプ ISSN
収録物識別子 10916490
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1073/pnas.91.15.7184
関連名称 10.1073/pnas.91.15.7184
権利
権利情報 © National Academy of Sciences
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