| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-10-09 |
| タイトル |
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タイトル |
Structure, function, and evolution of mouse TL genes, nonclassical class I genes of the major histocompatibility complex |
| タイトル |
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タイトル |
Structure, function, and evolution of mouse TL genes, nonclassical class I genes of the major histocompatibility complex |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
OBATA, Yuichi
SATTA, Yoko
MORIWAKI, Kazuo
SHIROISHI, Toshihiko
HASEGAWA, Hitomi
TAKAHASHI, Toshitada
TAKAHATA, Naoyuki
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
In contrast to well-studied "classical" class I genes of the major histocompatibility complex (MHC), the biology of nonclassical class I genes remains largely unexamined. The mouse TL genes constitute one of the best defined systems among nonclassical class I genes in the T region of the MHC. To elucidate the function and the evolution of TL genes and their relationship to classical class I genes, seven TL DNA sequences, including one from a Japanese wild mouse, were examined and compared with those of several mouse and human classical class I genes. The TL genes differ from either classical class I genes or pseudogenes in the extent and pattern of nucleotide substitutions. Natural selection appears to have operated so as to preserve the function of TL, which might have been acquired in an early stage of its evolution. In a putative peptide-binding region encoded by TL genes, the rate of nonsynonymous (amino acid replacing) substitution is considerably lower than that of synonymous substitution. This conservation is completely opposite that in classical class I genes, in which the peptide-binding region has evolved to diversify amino acid sequences so as to recognize a variety of antigens. Thus, it is suggested that the function of TL antigens is distinct from that of classical class I antigens and is related to the recognition of a relatively restricted repertoire of antigens and their presentation to T-cell receptors. |
| 書誌情報 |
Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America
巻 91,
号 14,
p. 6589-6593,
発行日 1994-07-05
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| 出版者 |
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出版者 |
National Academy of Sciences |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
10916490 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
8022824 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1073/pnas.91.14.6589 |
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関連名称 |
10.1073/pnas.91.14.6589 |
| 権利 |
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権利情報 |
© National Academy of Sciences |
