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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Structure, function, and evolution of mouse TL genes, nonclassical class I genes of the major histocompatibility complex

https://ir.soken.ac.jp/records/4005
https://ir.soken.ac.jp/records/4005
7ed8993d-3203-4f54-931f-c4965a7c9b5c
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-10-09
タイトル
タイトル Structure, function, and evolution of mouse TL genes, nonclassical class I genes of the major histocompatibility complex
タイトル
タイトル Structure, function, and evolution of mouse TL genes, nonclassical class I genes of the major histocompatibility complex
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 OBATA, Yuichi

× OBATA, Yuichi

OBATA, Yuichi

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SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

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MORIWAKI, Kazuo

× MORIWAKI, Kazuo

MORIWAKI, Kazuo

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SHIROISHI, Toshihiko

× SHIROISHI, Toshihiko

SHIROISHI, Toshihiko

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HASEGAWA, Hitomi

× HASEGAWA, Hitomi

HASEGAWA, Hitomi

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TAKAHASHI, Toshitada

× TAKAHASHI, Toshitada

TAKAHASHI, Toshitada

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 In contrast to well-studied "classical" class I genes of the major histocompatibility complex (MHC), the biology of nonclassical class I genes remains largely unexamined. The mouse TL genes constitute one of the best defined systems among nonclassical class I genes in the T region of the MHC. To elucidate the function and the evolution of TL genes and their relationship to classical class I genes, seven TL DNA sequences, including one from a Japanese wild mouse, were examined and compared with those of several mouse and human classical class I genes. The TL genes differ from either classical class I genes or pseudogenes in the extent and pattern of nucleotide substitutions. Natural selection appears to have operated so as to preserve the function of TL, which might have been acquired in an early stage of its evolution. In a putative peptide-binding region encoded by TL genes, the rate of nonsynonymous (amino acid replacing) substitution is considerably lower than that of synonymous substitution. This conservation is completely opposite that in classical class I genes, in which the peptide-binding region has evolved to diversify amino acid sequences so as to recognize a variety of antigens. Thus, it is suggested that the function of TL antigens is distinct from that of classical class I antigens and is related to the recognition of a relatively restricted repertoire of antigens and their presentation to T-cell receptors.
書誌情報 Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America

巻 91, 号 14, p. 6589-6593, 発行日 1994-07-05
出版者
出版者 National Academy of Sciences
ISSN
収録物識別子タイプ ISSN
収録物識別子 10916490
PubMed番号
識別子タイプ PMID
関連識別子 8022824
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1073/pnas.91.14.6589
関連名称 10.1073/pnas.91.14.6589
権利
権利情報 © National Academy of Sciences
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