| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-10-09 |
| タイトル |
|
|
タイトル |
The synonymous substitution rate of the major histocompatibility complex loci in primates |
| タイトル |
|
|
タイトル |
The synonymous substitution rate of the major histocompatibility complex loci in primates |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
SATTA, Yoko
O'hUIGIN, Colm
TAKAHATA, Naoyuki
KLEIN, Jan
|
| 著者別名 |
尚之, 高畑
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Because the divergence of many allelic lineages at the major histocompatibility complex (MHC) loci predates species divergence, standard methods of calculating synonymous substitution rates are not applicable to this system. We used three alternative methods of rate estimation: one based on the minimum number of substitutions (Dm), another on the nucleotide difference (Dxy), and the third on the net nucleotide difference (Dn). We applied these methods to the protein-encoding sequences of primate MHC class I (A, B, and C) and class II (DRB1) genes. To determine the reliability of the different estimates, we carried out computer simulation. The distribution of the estimates based on Dxy or Dn is generally much broader than that based on Dm. More importantly, the Dm-based method nearly always has the highest probability of recovering true rates, provided that Dm is not smaller than 5. Because of its desirable statistical properties, we used the Dm-based method to estimate the rate of synonymous substitutions. The rate is 1.37 +/- 0.61 for A, 1.84 +/- 0.40 for B, 3.87 +/- 1.05 for C, and 1.18 +/- 0.36 for DRB1 loci, always per site per 10(9) years. Hence despite the extraordinary polymorphism, the mutation rate at the primate MHC loci is no higher than that of other loci. |
| 書誌情報 |
Proceedings of the national academy of sciences of the united states of america
en : Proceedings of the national academy of sciences of the united states of america
巻 90,
号 16,
p. 7480-7484,
発行日 1993-08-15
|
| 出版者 |
|
|
出版者 |
National Academy of Sciences |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
10916490 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1073/pnas.90.16.7480 |
|
|
関連名称 |
10.1073/pnas.90.16.7480 |
| 権利 |
|
|
権利情報 |
© National Academy of Sciences |
