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  1. 010 学術雑誌論文
  2. 渡辺, 正勝 / WATANABE, Masakatsu

Action Spectrum Analysis of UVR Genotoxicity for Skin: The Border Wavelengths between UVA and UVB Can Bring Serious Mutation Loads to Skin

https://ir.soken.ac.jp/records/4007
https://ir.soken.ac.jp/records/4007
abd107c3-5d5b-4b5e-97f1-5f750451c3b1
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-10-11
タイトル
タイトル Action Spectrum Analysis of UVR Genotoxicity for Skin: The Border Wavelengths between UVA and UVB Can Bring Serious Mutation Loads to Skin
タイトル
タイトル Action Spectrum Analysis of UVR Genotoxicity for Skin: The Border Wavelengths between UVA and UVB Can Bring Serious Mutation Loads to Skin
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 IKEHATA, Hironobu

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IKEHATA, Hironobu

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WATANABE, Masakatsu

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WATANABE, Masakatsu

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et, al.

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et, al.

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著者別名 渡辺, 正勝

× 渡辺, 正勝

渡辺, 正勝

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抄録
内容記述タイプ Abstract
内容記述 UVR causes erythema, which has been used as a standardized index to evaluate the risk of UVR for human skin. However, the genotoxic significance of erythema has not been elucidated clearly. Here, we characterized the wavelength dependence of the genotoxic and erythematic effects of UVR for the skin by analyzing the induction kinetics of mutation and inflammation in mouse skin using lacZ-transgenic mice and monochromatic UVR sources. We determined their action spectra and found a close correlation between erythema and an epidermis-specific antigenotoxic response, mutation induction suppression (MIS), which suppressed the mutant frequencies (MFs) to a constant plateau level only 2–3-fold higher than the background MF at the cost of apoptotic cell death, suggesting that erythema may represent the threshold beyond which the antigenotoxic but tissue-destructive MIS response commences. However, we unexpectedly found that MIS attenuates remarkably at the border wavelengths between UVA and UVB around 315 nm, elevating the MF plateaus up to levels ~40-fold higher than the background level. Thus, these border wavelengths can bring heavier mutation loads to the skin than the otherwise more mutagenic and erythematic shorter wavelengths, suggesting that erythema-based UVR risk evaluation should be reconsidered.
書誌情報 Journal of Investigative Dermatology
en : Journal of Investigative Dermatology

巻 133, p. 1850-1856, 発行日 2013-02-14
出版者
出版者 Nature Publishing Group
ISSN
収録物識別子タイプ ISSN
収録物識別子 0022-202X
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/jid.2012.504
関連名称 10.1038/jid.2012.504
権利
権利情報 © 2013 Society for Investigative Dermatology
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