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  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Numerical studies of the frequency trajectories in the process of fixation of null genes at duplicated loci

https://ir.soken.ac.jp/records/4026
https://ir.soken.ac.jp/records/4026
df43768b-76c2-4ba1-a951-bc32c08ae8cc
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-10-24
タイトル
タイトル Numerical studies of the frequency trajectories in the process of fixation of null genes at duplicated loci
タイトル
タイトル Numerical studies of the frequency trajectories in the process of fixation of null genes at duplicated loci
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 MARUYAMA, Takeo

× MARUYAMA, Takeo

MARUYAMA, Takeo

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 A new numerical method, based on the stochastic differential equations, has been applied to the problem of the fixation of null alleles at duplicated loci. The results reported here were obtained under the assumption that individuals carrying homozygous null genes at both of the duplicated loci are lethal, but all the other genotypes are normal. The mean and median time for null alleles to fix can vary from 2N to 100N or more, depending on the mutation rate and the population size, where N is the population size. Linkage has strong effects on the fate of null genes in the populations, if 2Nc is of the order of 100 or less (c = recombination value). When the linkage is loose the frequencies of null genes in the course of fixation stay in a region where the frequency of the null gene is very low at one of the two duplicated loci. If the two loci are tightly linked, the fate of null genes at duplicated loci is determined by the mutation pressure and the random genetic drift, and selection plays a minor role. In these cases, the fixation time is invariably reduced and the trajectories can cover the entire region where the sum of null allele frequencies does not exceed unity. This makes the prediction that there should be rapid evolution of linked silent genes and pseudo-genes, and that silent DNA might be found close to functional genes.
書誌情報 Heredity
en : Heredity

巻 46, p. 49-57, 発行日 1981
出版者
出版者 Nature Publishing Group
ISSN
収録物識別子タイプ ISSN
収録物識別子 0018-067X
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/hdy.1981.5
関連名称 10.1038/hdy.1981.5
権利
権利情報 © 2013 The Genetics Society
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