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  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Polymorphism at MHC loci and isolation by the immune system in vertebrates.

https://ir.soken.ac.jp/records/4036
https://ir.soken.ac.jp/records/4036
12ecd78a-da96-4efb-b989-800197814e64
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-10-25
タイトル
タイトル Polymorphism at MHC loci and isolation by the immune system in vertebrates.
タイトル
タイトル Polymorphism at MHC loci and isolation by the immune system in vertebrates.
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 The major histocompatibility complex (Mhc) contains a family of genes whose products play crucial roles in self and nonself discrimination. Self is the mature T cell repertoire that is restricted by Mhc molecules, whereas nonself is processed peptides of foreign antigens that can be presented in the context of Mhc. Because the T cell repertoire and the complex of Mhc-peptides provide a molecular basis of self defense mechanism and both of them depend critically onMhc genotypes, the genes must be subjected to natural selection to some extent. A model of individual fitness is formulated in terms of the number of functionalMhc loci, the number of heterozygous loci, the size of T cell repertoire, and the size of Mhc peptide repertoire. Available data delimit the range of values of these parameters in the model. The mode of natural selection onMhc loci depends primarily on the T cell repertoire shaped by different gene products. If eachMhc gene product deletes a substantial portion of T cells, balancing selection cannot operate simultaneously on a large number of loci. Only when the number of functionalMhc loci is limited, natural selection acts so as to produce the unusual polymorphism. However, if individuals are heterozygous at all these loci or possess haplotypes being different in the constellation ofMhc loci, their fitness may be reduced. The reduction may happen in hybrids between antigenically diverged populations, in which case the immune system acts as a reproductive isolation mechanism.
書誌情報 Non-Neutral Evolution
en : Non-Neutral Evolution

p. 233-246, 発行日 1994
出版者
出版者 SpringerLink
ISBN
識別子タイプ ISBN
関連識別子 978-0-412-05391-7
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/978-1-4615-2383-3_19
関連名称 10.1007/978-1-4615-2383-3_19
権利
権利情報 SpringerLink(The original publication is available at www.springerlink.com)
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