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Polymorphism at MHC loci and isolation by the immune system in vertebrates.
https://ir.soken.ac.jp/records/4036
https://ir.soken.ac.jp/records/403612ecd78a-da96-4efb-b989-800197814e64
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2013-10-25 | |||||||
| タイトル | ||||||||
| タイトル | Polymorphism at MHC loci and isolation by the immune system in vertebrates. | |||||||
| タイトル | ||||||||
| タイトル | Polymorphism at MHC loci and isolation by the immune system in vertebrates. | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| アクセス権 | ||||||||
| アクセス権 | metadata only access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||
| 著者 |
TAKAHATA, Naoyuki
× TAKAHATA, Naoyuki
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| 著者別名 |
尚之, 高畑
× 尚之, 高畑
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The major histocompatibility complex (Mhc) contains a family of genes whose products play crucial roles in self and nonself discrimination. Self is the mature T cell repertoire that is restricted by Mhc molecules, whereas nonself is processed peptides of foreign antigens that can be presented in the context of Mhc. Because the T cell repertoire and the complex of Mhc-peptides provide a molecular basis of self defense mechanism and both of them depend critically onMhc genotypes, the genes must be subjected to natural selection to some extent. A model of individual fitness is formulated in terms of the number of functionalMhc loci, the number of heterozygous loci, the size of T cell repertoire, and the size of Mhc peptide repertoire. Available data delimit the range of values of these parameters in the model. The mode of natural selection onMhc loci depends primarily on the T cell repertoire shaped by different gene products. If eachMhc gene product deletes a substantial portion of T cells, balancing selection cannot operate simultaneously on a large number of loci. Only when the number of functionalMhc loci is limited, natural selection acts so as to produce the unusual polymorphism. However, if individuals are heterozygous at all these loci or possess haplotypes being different in the constellation ofMhc loci, their fitness may be reduced. The reduction may happen in hybrids between antigenically diverged populations, in which case the immune system acts as a reproductive isolation mechanism. | |||||||
| 書誌情報 |
Non-Neutral Evolution en : Non-Neutral Evolution p. 233-246, 発行日 1994 |
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| 出版者 | ||||||||
| 出版者 | SpringerLink | |||||||
| ISBN | ||||||||
| 識別子タイプ | ISBN | |||||||
| 関連識別子 | 978-0-412-05391-7 | |||||||
| DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1007/978-1-4615-2383-3_19 | |||||||
| 関連名称 | 10.1007/978-1-4615-2383-3_19 | |||||||
| 権利 | ||||||||
| 権利情報 | SpringerLink(The original publication is available at www.springerlink.com) | |||||||
