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Role of the molten globule state in protein folding
https://ir.soken.ac.jp/records/4299
https://ir.soken.ac.jp/records/42993ed47605-534b-4ce0-9e88-158b8ad801ac
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-03-14 | |||||
| タイトル | ||||||
| タイトル | Role of the molten globule state in protein folding | |||||
| タイトル | ||||||
| タイトル | Role of the molten globule state in protein folding | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
ARAI, Munehito
× ARAI, Munehito× KUWAJIMA, Kunihiro |
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| 著者別名 |
桑島, 邦博
× 桑島, 邦博 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Publisher Summary This chapter deals with the structure of the molten globules of various globular proteins revealed by the recent experimental studies. Recent advances in experimental techniques, including hydrogen-exchange NMR, solution X-ray scattering, and protein engineering, have provided detailed pictures of the molten globules for these proteins. The molten globule state has heterogeneous structures, in which one portion of a molecule is more organized and native-like with the other portions being less organized, although the overall structure satisfies the criteria of the molten globule state (compactness, the presence of secondary structure, and the lack of rigid tertiary structure). The chapter describes how the molten globule state has been identified as the intermediate of kinetic refolding and discusses the kinetic roles of the molten globule state in protein folding. The chapter also discusses thermodynamic stability and cooperativity of the molten globule state from the viewpoint of the hierarchy of protein folding, in which the molten globule state plays a role as a junction of two levels of the hierarchy. We dedicate this review to the late Prof. Dr. Oleg Borisovich Ptitsyn, who passed away during our preparation of this article. |
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| 書誌情報 |
Advances in Protein Chemistry en : Advances in Protein Chemistry 巻 53, p. 209-282, 発行日 2000 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0065-3233 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/S0065-3233(00)53005-8 | |||||
| 関連名称 | 10.1016/S0065-3233(00)53005-8 | |||||
| 権利 | ||||||
| 権利情報 | © 2000 Published by Elsevier Inc. | |||||
