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Fast Compaction of α-Lactalbumin During Folding Studied by Stopped-flow X-ray Scattering
https://ir.soken.ac.jp/records/4307
https://ir.soken.ac.jp/records/43077925570d-9c2c-48a4-86f6-ae40f67ed51e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2014-03-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Fast Compaction of α-Lactalbumin During Folding Studied by Stopped-flow X-ray Scattering | |||||||||||
| タイトル | ||||||||||||
| タイトル | Fast Compaction of α-Lactalbumin During Folding Studied by Stopped-flow X-ray Scattering | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | metadata only access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||||
| 著者 |
ARAI, Munehito
× ARAI, Munehito
× KUWAJIMA, Kunihiro
× et, al.
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| 著者別名 |
桑島, 邦博
× 桑島, 邦博
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | To monitor the fast compaction process during protein folding, we have used a stopped-flow small-angle X-ray scattering technique combined with a two-dimensional charge-coupled device-based X-ray detector that makes it possible to improve the signal-to-noise ratio of data dramatically, and measured the kinetic refolding reaction of α-lactalbumin. The results clearly show that the radius of gyration and the overall shape of the kinetic folding intermediate of α-lactalbumin are the same as those of the molten globule state observed at equilibrium. Thus, the identity between the kinetic folding intermediate and the equilibrium molten globule state is firmly established. The present results also suggest that the folding intermediate is more hydrated than the native state and that the hydrated water molecules are dehydrated when specific side-chain packing is formed during the change from the molten globule to the native state. | |||||||||||
| 書誌情報 |
Journal of Molecular Biology en : Journal of Molecular Biology 巻 321, 号 1, p. 121-132, 発行日 2002-08-02 |
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| 出版者 | ||||||||||||
| 出版者 | Elsevier | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0022-2836 | |||||||||||
| DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1016/S0022-2836(02)00566-1 | |||||||||||
| 関連名称 | 10.1016/S0022-2836(02)00566-1 | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | © 2002 Published by Elsevier Ltd. | |||||||||||
