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  1. 010 学術雑誌論文
  2. 桑島, 邦博 / KUWAJIMA, Kunihiro

Unification of the folding mechanisms of non-two-state and two-state proteins.

https://ir.soken.ac.jp/records/4317
https://ir.soken.ac.jp/records/4317
63b7fcd5-0268-407e-9cea-0437e9f98ee5
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-03-19
タイトル
タイトル Unification of the folding mechanisms of non-two-state and two-state proteins.
タイトル
タイトル Unification of the folding mechanisms of non-two-state and two-state proteins.
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 KAMAGATA, Kiyoto

× KAMAGATA, Kiyoto

KAMAGATA, Kiyoto

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ARAI, Munehito

× ARAI, Munehito

ARAI, Munehito

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KUWAJIMA, Kunihiro

× KUWAJIMA, Kunihiro

KUWAJIMA, Kunihiro

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著者別名 桑島, 邦博

× 桑島, 邦博

桑島, 邦博

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抄録
内容記述タイプ Abstract
内容記述 We have collected the kinetic folding data for non-two-state and two-state globular proteins reported in the literature, and investigated the relationships between the folding kinetics and the native three-dimensional structure of these proteins. The rate constants of formation of both the intermediate and the native state of non-two-state folders were found to be significantly correlated with protein chain length and native backbone topology, which is represented by the absolute contact order and sequence-distant native pairs. The folding rate of two-state folders, which is known to be correlated with the native backbone topology, apparently does not correlate significantly with protein chain length. On the basis of a comparison of the folding rates of the non-two-state and two-state folders, it was found that they are similarly dependent on the parameters that reflect the native backbone topology. This suggests that the mechanisms behind non-two-state and two-state folding are essentially identical. The present results lead us to propose a unified mechanism of protein folding, in which folding occurs in a hierarchical manner, reflecting the hierarchy of the native three-dimensional structure, as embodied in the case of non-two-state folding with an accumulation of the intermediate. Apparently, two-state folding is merely a simplified version of hierarchical folding caused either by an alteration in the rate-limiting step of folding or by destabilization of the intermediate.
書誌情報 Journal of Molecular Biology
en : Journal of Molecular Biology

巻 339, 号 4, p. 951-965, 発行日 2004-06-11
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 0022-2836
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jmb.2004.04.015
関連名称 10.1016/j.jmb.2004.04.015
権利
権利情報 © 2004 Elsevier Ltd.
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