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  1. 010 学術雑誌論文
  2. 桑島, 邦博 / KUWAJIMA, Kunihiro

Surprisingly high correlation between early and late stages in non-two-state protein folding

https://ir.soken.ac.jp/records/4328
https://ir.soken.ac.jp/records/4328
53a6a626-3d35-4554-b30a-471664f5f6e6
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-03-24
タイトル
タイトル Surprisingly high correlation between early and late stages in non-two-state protein folding
タイトル
タイトル Surprisingly high correlation between early and late stages in non-two-state protein folding
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 KAMAGATA, Kiyoto

× KAMAGATA, Kiyoto

KAMAGATA, Kiyoto

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KUWAJIMA, Kunihiro

× KUWAJIMA, Kunihiro

KUWAJIMA, Kunihiro

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著者別名 桑島, 邦博

× 桑島, 邦博

桑島, 邦博

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抄録
内容記述タイプ Abstract
内容記述 We collected quantitative kinetic data on early and late stages of folding in non-two-state proteins from the literature, and studied the relationship between the kinetics of the two stages. There was a surprisingly high correlation between the rate constants of these stages. The correlation coefficient of the logarithmic rate constants was as high as 0.97, which could not be caused by chance. We also studied relationships of the logarithmic rate constants of the two stages with native three-dimensional structures represented by the residue–residue contact map. There were again surprisingly high correlations between the logarithmic rate constants and the number of non-local contact clusters obtained from the contact maps. Because the number of non-local contact clusters represents overall arrangement of substructures in a native protein, the results strongly suggested the importance of the arrangement of the substructures for the kinetics of both early and late stages of protein folding.
書誌情報 Journal of Molecular Biology
en : Journal of Molecular Biology

巻 357, 号 5, p. 1647-1654, 発行日 2006-04-14
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 0022-2836
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jmb.2006.01.072
関連名称 10.1016/j.jmb.2006.01.072
権利
権利情報 © 2006 Elsevier Ltd.
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